Hormone Supplementation during aging: How much and when?

K. G. Sorwell; J. Garten; L. Renner; A. Weiss; V. T. Garyfallou; S. G. Kohama; M. Neuringer; H. F. Urbanski

doi:10.1089/rej.2011.1251

Hormone Supplementation during aging: How much and when?

K. G. Sorwell, J. Garten, L. Renner, A. Weiss, V. T. Garyfallou, S. G. Kohama, M. Neuringer, H. F. Urbanski

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8 Scopus citations

Abstract

Circulating levels of dehydroepiandrosterone, a major adrenal steroid, show a marked age-related decrease in both humans and nonhuman primates. Because this decrease has been implicated in age-related cognitive decline, we administered supplementary dehydroepiandrosterone to perimenopausal rhesus macaques (Macaca mulatta) to test for cognitive benefits. Although recognition memory improved, there was no benefit to spatial working memory. To address the limitations of this study we developed a hormone supplementation regimen in aged male macaques that more accurately replicates the 24-hr androgen profiles of young animals. We hypothesize that this more comprehensive physiological hormone replacement paradigm will enhance cognitive function in the elderly.

Original language	English (US)
Pages (from-to)	128-131
Number of pages	4
Journal	Rejuvenation Research
Volume	15
Issue number	2
DOIs	https://doi.org/10.1089/rej.2011.1251
State	Published - Apr 1 2012
Externally published	Yes

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10.1089/rej.2011.1251

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title = "Hormone Supplementation during aging: How much and when?",

abstract = "Circulating levels of dehydroepiandrosterone, a major adrenal steroid, show a marked age-related decrease in both humans and nonhuman primates. Because this decrease has been implicated in age-related cognitive decline, we administered supplementary dehydroepiandrosterone to perimenopausal rhesus macaques (Macaca mulatta) to test for cognitive benefits. Although recognition memory improved, there was no benefit to spatial working memory. To address the limitations of this study we developed a hormone supplementation regimen in aged male macaques that more accurately replicates the 24-hr androgen profiles of young animals. We hypothesize that this more comprehensive physiological hormone replacement paradigm will enhance cognitive function in the elderly.",

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AU - Sorwell, K. G.

AU - Garten, J.

AU - Renner, L.

AU - Weiss, A.

AU - Garyfallou, V. T.

AU - Kohama, S. G.

AU - Neuringer, M.

AU - Urbanski, H. F.

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Hormone Supplementation during aging: How much and when?

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