Hormone Replacement and Cardiovascular Risk Factors

Barnett Zumoff, David Crook, John C. Stevenson, J. C. Daubresse, Avrum Z. Bluming, Azmi A. Nabulsi, Aaron R. Folsom, Alice White, Kathryn A. Martin, Mason W. Freeman

Research output: Contribution to journalLetterpeer-review

5 Scopus citations

Abstract

To the Editor: Nabulsi et al. (April 15 issue)1 present convincing data that postmenopausal hormone-replacement therapy, whether with estrogen alone or with estrogen and progestin, greatly decreases the risk of cardiovascular disease. In their editorial, Martin and Freeman reiterate what has become almost conventional wisdom – namely, that replacement therapy with progestins “attenuates [the] beneficial effects of estrogen on lipid levels” and therefore, presumably, may weaken the protective effect of estrogen-replacement therapy against cardiovascular disease2. I should like to cite a number of studies that offer reassurance that progestins probably do not have such a deleterious effect. Two recent…

Original languageEnglish (US)
Pages (from-to)1041-1043
Number of pages3
JournalNew England Journal of Medicine
Volume329
Issue number14
DOIs
StatePublished - Sep 30 1993

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