Hormonal release of programmed behavior in silk moths

Probable mediation by cyclic AMP

James W. Truman, Ann Marie Fallon, G. R. Wyatt

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The eclosion hormone triggers a stereotyped preprogrammed pattern of behavior in silk moths. The effects of the hormone were duplicated by the injection of dibutyryl adenosine 3′,5′-monophosphate, adenosine 3′,5′-monophosphate (cyclic AMP), or guanosine 3′,5′- monophosphate (cyclic GMP) into theophylline-treated pharate moths. Treatment with theophylline reduced the latency of the response to a low dose of hormone, presumably by blocking phosphodiesterase. Endogenous levels of cyclic AMP, but not cyclic GMP, increased significantly in the central nervous system within 10 minutes after hormone injection. We conclude that an early step leading to the release of the eclosion motor program is an increase in cyclic AMP in target neurons of the central nervous system.

Original languageEnglish (US)
Pages (from-to)1432-1434
Number of pages3
JournalScience
Volume194
Issue number4272
DOIs
StatePublished - Jan 1 1976

Fingerprint

Silk
Moths
Cyclic AMP
Hormones
Theophylline
Central Nervous System
Guanosine Monophosphate
Injections
Phosphoric Diester Hydrolases
Adenosine Monophosphate
Adenosine
Reaction Time
Neurons
Therapeutics

Cite this

Hormonal release of programmed behavior in silk moths : Probable mediation by cyclic AMP. / Truman, James W.; Marie Fallon, Ann; Wyatt, G. R.

In: Science, Vol. 194, No. 4272, 01.01.1976, p. 1432-1434.

Research output: Contribution to journalArticle

Truman, James W. ; Marie Fallon, Ann ; Wyatt, G. R. / Hormonal release of programmed behavior in silk moths : Probable mediation by cyclic AMP. In: Science. 1976 ; Vol. 194, No. 4272. pp. 1432-1434.
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