Hormonal Effects on Bone Cells

Teresita Bellido, Kathleen M. Hill Gallant

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations


This chapter focuses on the direct effects of systemic hormones on the skeleton. Parathyroid hormone increases bone formation and resorption by acting through receptors expressed in cells of the osteoblastic lineage, and exerts catabolic or anabolic effects depending on the mechanism of elevation (continuous or intermittent). The sex steroids, androgens and estrogens, protect the growing and mature skeleton through receptors expressed in osteoblasts, as well as in osteoclasts, by maintaining the balance between bone formation and resorption. Glucocorticoids, when present in excess due to endogenous elevation or to administration as immunosuppressant therapy, have deleterious effects on bone resulting from acceleration of bone resorption, inhibition of bone formation, and increased bone fragility. Other hormones, such as thyroid hormone, growth hormone, insulin, 1,25-dihydroxyvitamin D3, and leptin affect bone development and homeostasis of the mature skeleton by acting on bone cells of both mesenchymal and hematopoietic lineages.

Original languageEnglish (US)
Title of host publicationBasic and Applied Bone Biology
PublisherElsevier Inc.
Number of pages16
ISBN (Print)9780124160156
StatePublished - Aug 12 2013
Externally publishedYes


  • Androgens
  • Estrogens
  • Glucocorticoids
  • Growth hormone
  • Insulin
  • Leptin
  • Parathyroid hormone
  • Thyroid hormone
  • Vitamin D3


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