Homogeneous gold-catalyzed oxidative carboheterofunctionalization of alkenes

Guozhu Zhang, Li Cui, Yanzhao Wang, Liming Zhang

Research output: Contribution to journalArticlepeer-review

282 Scopus citations

Abstract

(Chemical Equation Presented) Homogeneous carboamination, carboalkoxylation and carbolactonization of terminal alkenes are realized via oxidative gold catalysis, providing expedient access to various substituted Nor O-heterocycles. Deuterium-labeling studies established the anti nature of the alkene functionalization and the indispensible role of Au(I)/Au(III) catalysis. This study constitutes the first example of catalytically converting C(sp 3)-Au bonds into C(sp3)-C(sp2) bonds in a crosscoupling manner and opens new opportunities to study gold alkene catalysis where alkylgold intermediates can be readily functionalized intermolecularly.

Original languageEnglish (US)
Pages (from-to)1474-1475
Number of pages2
JournalJournal of the American Chemical Society
Volume132
Issue number5
DOIs
StatePublished - Feb 10 2010

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