Homeostatic expansion occurs independently of costimulatory signals

Research output: Contribution to journalArticlepeer-review

94 Scopus citations

Abstract

Naive T cells undergo homeostatic proliferation in lymphopenic mice, a process that involves TCR recognition of specific self peptide/MHC complexes. Since costimulation signals regulate the T cell response to foreign Ags, we asked whether they also regulate homeostatic expansion. We report in this study that homeostatic expansion of CD4 and CD8 T cells occurs independently of costimulation signals mediated through CD28/B7, CD40L/CD40, or 4-1BB/4-1BBL interactions. Using DO11.10 TCR transgenic T cells, we confirmed that CD28 expression was dispensable for homeostatic expansion, and showed that the presence of endogenous CD4+CD25+ regulatory cells did not detectably influence homeostatic expansion. The implications of these findings with respect to regulation of T cell homeostasis and autoimmunity are discussed.

Original languageEnglish (US)
Pages (from-to)5664-5668
Number of pages5
JournalJournal of Immunology
Volume167
Issue number10
DOIs
StatePublished - Nov 15 2001

Fingerprint Dive into the research topics of 'Homeostatic expansion occurs independently of costimulatory signals'. Together they form a unique fingerprint.

Cite this