Hodgkin’s disease in children: Correlation of clinical characteristics, staging procedures, and treatment at the university of minnesota

Kenneth L. McClain, Robin Heise, Deborah L. Day, Chung K.K. Lee, William G. Woods, Dorothee Aeppli

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The cases of 63 children treated for Hodgkin’s disease were retrospectively evaluated according to clinical and laboratory characteristics at initial appearance, clinical and pathologic staging, and treatment for their effects on survival and disease-free survival. An initial erythrocyte sedimentation rate over 50 mrn/h was common in patients who ultimately had a relapse. There was no correlation between the size of the mediastinal mass at diagnosis and occurrence of relapse. A residual mediastinal mass was found in 22% of patients after 1 year of treatment regardless of its size at initial appearance. With a median followup time of 10.5 years, the overall survival rate is 89%, and disease-free survival rate is 71%. The disease-free survival rates for patients with stages I-IV disease are 92, 81, 78, and 40%, respectively. Relapses occurred in 7 of 22 (36%) patients with positive staging laparotomy despite radiotherapy for three with stage IA and IIA disease, chemotherapy alone for two with stage IIIB disease, or chemotherapy for one with stage IIIB and one with stage IVB disease. Of patients who had no evidence of abdominal Hodgkin’s disease at a staging laparotomy, 6 of 34 (19%) had a relapse. These included one with stage IA and five stage IIA disease, all treated with radiotherapy alone. Treatment of stage III and IV disease with regimens including CCNU (lomustine) or cyclophosphamide, plus vinblastine sulfate or vincristine sulfate, prednisone, and procarbazine hydrochloride with or without radiation therapy yielded poor results, with 6/7 having a relapse.

Original languageEnglish (US)
Pages (from-to)147-154
Number of pages8
JournalAmerican Journal of Pediatric Hematology/Oncology
Volume12
Issue number2
StatePublished - 1990

Keywords

  • Children
  • Erythrocyte sedimentation rate
  • Hodgkin’s disease
  • Mediastinal mass
  • Staging
  • Treatment

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