Abstract
Background Hmong men in Minnesota exhibit a high prevalence of gout and hyperuricemia. Although evidence of vitamin C’s effectiveness as a treatment for gout is mixed, analysis of therapeutic benefit based on an individual’s multiomic signature may identify predictive markers of treatment success. Objectives The primary objective of the Hmong Microbiome ANd Gout, Obesity, Vitamin C (HMANGO-C) study was to assess the effectiveness of vitamin C on serum urate in Hmong adults with and without gout/hyperuricemia. The secondary objectives were to assess if 1) vitamin C impacts the taxonomic and functional patterns of microbiota; 2) taxonomic and functional patterns of microbiota impact vitamin C’s urate-lowering effects; 3) genetic variations impact vitamin C’s urate-lowering effects; 4) differential microbial biomarkers exist for patients with or without gout; and 5) there is an association between obesity, gut microbiota and gout/ hyperuricemia. Methods This prospective open-labelled clinical trial was guided by community-based participatory research principles and conducted under research safety restrictions for SARS-CoV-2. We aimed to enroll a convenient sample of 180 Hmong adults (120 with gout/hyperuricemia and 60 without gout/hyperuricemia) who provided medical, demographic, dietary and anthropometric information. Participants took vitamin C 500mg twice daily for 8 weeks and provided pre-and post- samples of blood and urine for urate measurements as well as stool samples for gut microbiome. Salivary DNA was also collected for genetic markers relevant to uric acid disposition. Expected results We expected to quantify the impact of vitamin C on serum urate in Hmong adults with and without gout/hyperuricemia. The outcome will enhance our understanding of how gut microbiome and genomic variants impact the urate-lowering of vitamin C and associations between obesity, gut microbiota and gout/hyperuricemia. Ultimately, findings may improve our understanding of the causes and potential interventions that could be used to address health disparities in the prevalence and management of gout in this underserved population. Trial registration ClinicalTrials.gov NCT04938024 (first posted: 06/24/2021).
| Original language | English (US) |
|---|---|
| Article number | e0279830 |
| Journal | PloS one |
| Volume | 18 |
| Issue number | 2 February |
| DOIs | |
| State | Published - Feb 2023 |
Bibliographical note
Funding Information:This study was also supported by the University of Minnesota Clinical and Translational Science Institute, the Graduate School at the University of Minnesota, University of Minnesota and National Institutes of Health’s National Center for Advancing Translational Sciences, grant UL1TR002494. The content is solely the responsibility of the authors and does not represent the official views of the National Institutes of Health’s National Center for Advancing Translational Sciences. The authors wish to thank the support from all the study participants, members of Hmong Gout Coalition, the community advisory board: Jay Desai, Song Xiong, Lissee Thao, Maiyia Kasouaher, and Mai See Vang Moua, and members of SoLaHmo: Michelle Lo, Pa Jee Vang, and Colton Vue who provided important input and the recruitment of the participants. We also thank Charles Vang, a member of the Hmong 18 Council, who provided critical feedback on the study design and helped the promotion of the study.
Funding Information:
Funding:Thisstudywasalsosupportedbythe UniversityofMinnesotaClinicalandTranslational ScienceInstitute,theGraduateSchoolatthe UniversityofMinnesota,UniversityofMinnesota andNationalInstitutesofHealth’sNationalCenter forAdvancingTranslationalSciences,grant UL1TR002494.Thecontentissolelythe responsibilityoftheauthorsanddoesnot representtheofficialviewsoftheNational InstitutesofHealth’sNationalCenterforAdvancing TranslationalSciences.
Publisher Copyright:
© 2023 Wen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
