HLA typing used with cultured amniotic and chorionic villus cells for early prenatal diagnosis or parentage testing without one parent's availability

Cynthia Callaway, Catherine Falcon, Gloria Grant, David H. Maurer, Arleen D. Auerbach, Zev Rosenwaks, Marilyn S. Pollack

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Like fetal fibroblasts and amniotic fluid cells, cultured chorionic villus cells can also be HLA typed with selected typing sera after preincubation with gamma interferon to promote better antigen expression. A modified procedure now in use would also allow any of these cell types to be tested for the presence or absence of all known HLA A,B,C, and DR antigens with standard preplated typing trays. This procedure was used to confirm that an on-going pregnancy had resulted from the successful in vitro fertilization and implantation of an anonymous donor's ovum and could also be of major use in rape or artificial insemination cases when the identity of the possible father(s) is not known.

Original languageEnglish (US)
Pages (from-to)200-204
Number of pages5
JournalHuman Immunology
Volume16
Issue number2
DOIs
StatePublished - Jun 1986

Fingerprint Dive into the research topics of 'HLA typing used with cultured amniotic and chorionic villus cells for early prenatal diagnosis or parentage testing without one parent's availability'. Together they form a unique fingerprint.

Cite this