HLA-E: A novel HLA class I gene expressed in resting T lymphocytes

B. H. Koller, D. E. Geraghty, Yoji Shimizu, R. DeMars, Harry T Orr

Research output: Contribution to journalArticle

193 Citations (Scopus)

Abstract

A MHC class I gene, HLA-6.2, has been identified. Examination of its primary structure indicates that HLA-6.2 is the most divergent member of the class I gene family characterized to date. Tissue distribution of HLA-6.2 RNA differs from other class I genes in that the highest level of RNA is detected in resting T lymphocytes. After transfer of the HLA-6.2 gene into a class I null human lymphoblastoid cell line, a protein associated with β2-microglobulin is detected. Analysis of HLA deletion mutant cell lines places the HLA-6.2 gene between the HLA-C and HLA-A loci on the short arm of chromosome 6. These data support the fact that the HLA-6.2 gene is a distinct expressible HLA class I gene, which we propose be designated HLA-E.

Original languageEnglish (US)
Pages (from-to)897-904
Number of pages8
JournalJournal of Immunology
Volume141
Issue number3
StatePublished - Jan 1 1988

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MHC Class I Genes
T-Lymphocytes
RNA
HLA-C Antigens
Genes
Cell Line
Chromosomes, Human, Pair 6
HLA-A Antigens
Tissue Distribution
Proteins

Cite this

HLA-E : A novel HLA class I gene expressed in resting T lymphocytes. / Koller, B. H.; Geraghty, D. E.; Shimizu, Yoji; DeMars, R.; Orr, Harry T.

In: Journal of Immunology, Vol. 141, No. 3, 01.01.1988, p. 897-904.

Research output: Contribution to journalArticle

Koller, BH, Geraghty, DE, Shimizu, Y, DeMars, R & Orr, HT 1988, 'HLA-E: A novel HLA class I gene expressed in resting T lymphocytes', Journal of Immunology, vol. 141, no. 3, pp. 897-904.
Koller, B. H. ; Geraghty, D. E. ; Shimizu, Yoji ; DeMars, R. ; Orr, Harry T. / HLA-E : A novel HLA class I gene expressed in resting T lymphocytes. In: Journal of Immunology. 1988 ; Vol. 141, No. 3. pp. 897-904.
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