HLA-E: A novel HLA class I gene expressed in resting T lymphocytes

B. H. Koller, D. E. Geraghty, Y. Shimizu, R. DeMars, H. T. Orr

Research output: Contribution to journalArticlepeer-review

231 Scopus citations


A MHC class I gene, HLA-6.2, has been identified. Examination of its primary structure indicates that HLA-6.2 is the most divergent member of the class I gene family characterized to date. Tissue distribution of HLA-6.2 RNA differs from other class I genes in that the highest level of RNA is detected in resting T lymphocytes. After transfer of the HLA-6.2 gene into a class I null human lymphoblastoid cell line, a protein associated with β2-microglobulin is detected. Analysis of HLA deletion mutant cell lines places the HLA-6.2 gene between the HLA-C and HLA-A loci on the short arm of chromosome 6. These data support the fact that the HLA-6.2 gene is a distinct expressible HLA class I gene, which we propose be designated HLA-E.

Original languageEnglish (US)
Pages (from-to)897-904
Number of pages8
JournalJournal of Immunology
Issue number3
StatePublished - 1988


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