HLA-B27-associated bilateral Ménière disease

Shamila G. Rawal, Kunal H. Thakkar, Kasra Ziai, Peter A. Santi, Hamid R. Djalilian

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


We describe 2 cases of bilateral Ménière disease with features resembling autoimmune inner ear disease in patients who were found to be carriers of human leukocyte antigen (HLA) B27. For immunohistochemical analysis, mouse inner ear sections were used as the tissue substrate for reaction with serum. Both patients demonstrated an increased immunofluorescence reaction compared with a normal control. We suggest that an antibody-mediated mechanism may be responsible for HLA-B27-associated Ménière disease.

Original languageEnglish (US)
Pages (from-to)122-127
Number of pages6
JournalEar, Nose and Throat Journal
Issue number3
StatePublished - Mar 2010

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