HL-A and Lymphoid Tumors

Fred R. Dick; Athanasios Theologides; John Greally; Nancy Wood; Edmond J. Yunis

HL-A and Lymphoid Tumors

Fred R. Dick, Athanasios Theologides, John Greally, Nancy Wood, Edmond J. Yunis

Medicine - Hematology, Oncology, Transplant

Research output: Contribution to journal › Article › peer-review

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Abstract

The incidence of HL-A antigens on peripheral lymphocytes of 154 patients with lymphoid tumors has been compared with that of 383 controls. With the use of the simple χ²test and a 5% level of significance, seven different associations appear to be valid. However, when the p value is corrected by multiplying it by the number of factors investigated, only the association of HL-A12 with lymphocytic lymphomas and the 4c antigen with chronic lymphatic leukemia appear to be significant. The previously described increased incidence of W5 and 4c in Hodgkin's disease was not found in the population studied, nor was the HL-A2-12 phenotype found to be increased in acute lymphatic leukemia.

Original language	English (US)
Pages (from-to)	2608-2611
Number of pages	4
Journal	Cancer Research
Volume	32
Issue number	12
State	Published - Dec 1 1972

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Cite this

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year = "1972",

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T1 - HL-A and Lymphoid Tumors

AU - Dick, Fred R.

AU - Theologides, Athanasios

AU - Greally, John

AU - Wood, Nancy

AU - Yunis, Edmond J.

PY - 1972/12/1

Y1 - 1972/12/1

N2 - The incidence of HL-A antigens on peripheral lymphocytes of 154 patients with lymphoid tumors has been compared with that of 383 controls. With the use of the simple χ2test and a 5% level of significance, seven different associations appear to be valid. However, when the p value is corrected by multiplying it by the number of factors investigated, only the association of HL-A12 with lymphocytic lymphomas and the 4c antigen with chronic lymphatic leukemia appear to be significant. The previously described increased incidence of W5 and 4c in Hodgkin's disease was not found in the population studied, nor was the HL-A2-12 phenotype found to be increased in acute lymphatic leukemia.

AB - The incidence of HL-A antigens on peripheral lymphocytes of 154 patients with lymphoid tumors has been compared with that of 383 controls. With the use of the simple χ2test and a 5% level of significance, seven different associations appear to be valid. However, when the p value is corrected by multiplying it by the number of factors investigated, only the association of HL-A12 with lymphocytic lymphomas and the 4c antigen with chronic lymphatic leukemia appear to be significant. The previously described increased incidence of W5 and 4c in Hodgkin's disease was not found in the population studied, nor was the HL-A2-12 phenotype found to be increased in acute lymphatic leukemia.

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JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0099-7013

IS - 12

ER -

HL-A and Lymphoid Tumors

Abstract

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