TY - JOUR
T1 - HIV vaccine trial exploits a dual and central role for innate immunity
AU - Fuller, Deborah Heydenburg
AU - Richert-Spuhler, Laura E.
AU - Klatt, Nichole R.
N1 - Publisher Copyright:
© 2014, American Society for Microbiology.
PY - 2014
Y1 - 2014
N2 - Limited understanding of correlates of protection from HIV transmission hinders development of an efficacious vaccine. D. J. M. Lewis and colleagues (J. Virol. 88:11648 -11657, 2014, doi:10.1128/JVI.01621-14) now report that vaginal immunization with an HIVgp140 vaccine linked to the 70-kDa heat shock protein downregulated the human immunodeficiency virus (HIV) coreceptor CCR5 (chemokine [C-C motif] receptor 5) and increased expression of the HIV resistance factor APOBEC3G (apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3G), in women. These effects correlated with HIV suppression ex vivo. Thus, vaccine-induced innate responses not only facilitate adaptive immunity-they may prove to be critical for preventing HIV transmission.
AB - Limited understanding of correlates of protection from HIV transmission hinders development of an efficacious vaccine. D. J. M. Lewis and colleagues (J. Virol. 88:11648 -11657, 2014, doi:10.1128/JVI.01621-14) now report that vaginal immunization with an HIVgp140 vaccine linked to the 70-kDa heat shock protein downregulated the human immunodeficiency virus (HIV) coreceptor CCR5 (chemokine [C-C motif] receptor 5) and increased expression of the HIV resistance factor APOBEC3G (apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3G), in women. These effects correlated with HIV suppression ex vivo. Thus, vaccine-induced innate responses not only facilitate adaptive immunity-they may prove to be critical for preventing HIV transmission.
UR - http://www.scopus.com/inward/record.url?scp=84907907979&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907907979&partnerID=8YFLogxK
U2 - 10.1128/JVI.02140-14
DO - 10.1128/JVI.02140-14
M3 - Comment/debate
C2 - 25122775
AN - SCOPUS:84907907979
SN - 0022-538X
VL - 88
SP - 11640
EP - 11643
JO - Journal of virology
JF - Journal of virology
IS - 20
ER -
