HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck

Jonathan M Carlson; Malinda Schaefer; Daniela C Monaco; Rebecca Batorsky; Daniel T Claiborne; Jessica Prince; Martin J Deymier; Zachary S Ende; Nichole R Klatt; Charles E DeZiel; Tien-Ho Lin; Jian Peng; Aaron M Seese; Roger Shapiro; John Frater; Thumbi Ndung'u; Jianming Tang; Paul Goepfert; Jill Gilmour; Matt A Price; William Kilembe; David Heckerman; Philip J R Goulder; Todd M Allen; Susan Allen; Eric Hunter

doi:10.1126/science.1254031

HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck

Jonathan M Carlson
, Malinda Schaefer
, Daniela C Monaco
, Rebecca Batorsky
, Daniel T Claiborne
, Jessica Prince
, Martin J Deymier
, Zachary S Ende
, Nichole R Klatt
, Charles E DeZiel
, Tien-Ho Lin
, Jian Peng
, Aaron M Seese
, Roger Shapiro
, John Frater
, Thumbi Ndung'u
, Jianming Tang
, Paul Goepfert
, Jill Gilmour
, Matt A Price

William Kilembe, David Heckerman, Philip J R Goulder, Todd M Allen, Susan Allen, Eric Hunter

Research output: Contribution to journal › Article › peer-review

209 Scopus citations

Abstract

Heterosexual transmission of HIV-1 typically results in one genetic variant establishing systemic infection. We compared, for 137 linked transmission pairs, the amino acid sequences encoded by non-envelope genes of viruses in both partners and demonstrate a selection bias for transmission of residues that are predicted to confer increased in vivo fitness on viruses in the newly infected, immunologically naïve recipient. Although tempered by transmission risk factors, such as donor viral load, genital inflammation, and recipient gender, this selection bias provides an overall transmission advantage for viral quasispecies that are dominated by viruses with high in vivo fitness. Thus, preventative or therapeutic approaches that even marginally reduce viral fitness may lower the overall transmission rates and offer long-term benefits even upon successful transmission.

Original language	English (US)
Pages (from-to)	1254031
Journal	Science (New York, N.Y.)
Volume	345
Issue number	6193
DOIs	https://doi.org/10.1126/science.1254031
State	Published - Jul 11 2014
Externally published	Yes

Bibliographical note

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 5 Gender Equality

Keywords

Amino Acid Sequence
Consensus Sequence
DNA Mutational Analysis
Disease Transmission, Infectious/statistics & numerical data
Female
HIV Infections/transmission
HIV-1/genetics
Heterosexuality
High-Throughput Nucleotide Sequencing
Human Immunodeficiency Virus Proteins/genetics
Humans
Male
Models, Statistical
Molecular Sequence Data
Point Mutation
Risk Factors
Selection, Genetic
Viral Load

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Publisher link

10.1126/science.1254031

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Carlson, J. M., Schaefer, M., Monaco, D. C., Batorsky, R., Claiborne, D. T., Prince, J., Deymier, M. J., Ende, Z. S., Klatt, N. R., DeZiel, C. E., Lin, T.-H., Peng, J., Seese, A. M., Shapiro, R., Frater, J., Ndung'u, T., Tang, J., Goepfert, P., Gilmour, J., ... Hunter, E. (2014). HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck. Science (New York, N.Y.), 345(6193), 1254031. https://doi.org/10.1126/science.1254031

Carlson, JM, Schaefer, M, Monaco, DC, Batorsky, R, Claiborne, DT, Prince, J, Deymier, MJ, Ende, ZS, Klatt, NR, DeZiel, CE, Lin, T-H, Peng, J, Seese, AM, Shapiro, R, Frater, J, Ndung'u, T, Tang, J, Goepfert, P, Gilmour, J, Price, MA, Kilembe, W, Heckerman, D, Goulder, PJR, Allen, TM, Allen, S & Hunter, E 2014, 'HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck', Science (New York, N.Y.), vol. 345, no. 6193, pp. 1254031. https://doi.org/10.1126/science.1254031

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title = "HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck",

abstract = "Heterosexual transmission of HIV-1 typically results in one genetic variant establishing systemic infection. We compared, for 137 linked transmission pairs, the amino acid sequences encoded by non-envelope genes of viruses in both partners and demonstrate a selection bias for transmission of residues that are predicted to confer increased in vivo fitness on viruses in the newly infected, immunologically na{\"i}ve recipient. Although tempered by transmission risk factors, such as donor viral load, genital inflammation, and recipient gender, this selection bias provides an overall transmission advantage for viral quasispecies that are dominated by viruses with high in vivo fitness. Thus, preventative or therapeutic approaches that even marginally reduce viral fitness may lower the overall transmission rates and offer long-term benefits even upon successful transmission. ",

keywords = "Amino Acid Sequence, Consensus Sequence, DNA Mutational Analysis, Disease Transmission, Infectious/statistics \& numerical data, Female, HIV Infections/transmission, HIV-1/genetics, Heterosexuality, High-Throughput Nucleotide Sequencing, Human Immunodeficiency Virus Proteins/genetics, Humans, Male, Models, Statistical, Molecular Sequence Data, Point Mutation, Risk Factors, Selection, Genetic, Viral Load",

author = "Carlson, \{Jonathan M\} and Malinda Schaefer and Monaco, \{Daniela C\} and Rebecca Batorsky and Claiborne, \{Daniel T\} and Jessica Prince and Deymier, \{Martin J\} and Ende, \{Zachary S\} and Klatt, \{Nichole R\} and DeZiel, \{Charles E\} and Tien-Ho Lin and Jian Peng and Seese, \{Aaron M\} and Roger Shapiro and John Frater and Thumbi Ndung'u and Jianming Tang and Paul Goepfert and Jill Gilmour and Price, \{Matt A\} and William Kilembe and David Heckerman and Goulder, \{Philip J R\} and Allen, \{Todd M\} and Susan Allen and Eric Hunter",

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AU - Carlson, Jonathan M

AU - Schaefer, Malinda

AU - Monaco, Daniela C

AU - Batorsky, Rebecca

AU - Claiborne, Daniel T

AU - Prince, Jessica

AU - Deymier, Martin J

AU - Ende, Zachary S

AU - Klatt, Nichole R

AU - DeZiel, Charles E

AU - Lin, Tien-Ho

AU - Peng, Jian

AU - Seese, Aaron M

AU - Shapiro, Roger

AU - Frater, John

AU - Ndung'u, Thumbi

AU - Tang, Jianming

AU - Goepfert, Paul

AU - Gilmour, Jill

AU - Price, Matt A

AU - Kilembe, William

AU - Heckerman, David

AU - Goulder, Philip J R

AU - Allen, Todd M

AU - Allen, Susan

AU - Hunter, Eric

PY - 2014/7/11

Y1 - 2014/7/11

N2 - Heterosexual transmission of HIV-1 typically results in one genetic variant establishing systemic infection. We compared, for 137 linked transmission pairs, the amino acid sequences encoded by non-envelope genes of viruses in both partners and demonstrate a selection bias for transmission of residues that are predicted to confer increased in vivo fitness on viruses in the newly infected, immunologically naïve recipient. Although tempered by transmission risk factors, such as donor viral load, genital inflammation, and recipient gender, this selection bias provides an overall transmission advantage for viral quasispecies that are dominated by viruses with high in vivo fitness. Thus, preventative or therapeutic approaches that even marginally reduce viral fitness may lower the overall transmission rates and offer long-term benefits even upon successful transmission.

AB - Heterosexual transmission of HIV-1 typically results in one genetic variant establishing systemic infection. We compared, for 137 linked transmission pairs, the amino acid sequences encoded by non-envelope genes of viruses in both partners and demonstrate a selection bias for transmission of residues that are predicted to confer increased in vivo fitness on viruses in the newly infected, immunologically naïve recipient. Although tempered by transmission risk factors, such as donor viral load, genital inflammation, and recipient gender, this selection bias provides an overall transmission advantage for viral quasispecies that are dominated by viruses with high in vivo fitness. Thus, preventative or therapeutic approaches that even marginally reduce viral fitness may lower the overall transmission rates and offer long-term benefits even upon successful transmission.

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KW - Consensus Sequence

KW - DNA Mutational Analysis

KW - Disease Transmission, Infectious/statistics & numerical data

KW - Female

KW - HIV Infections/transmission

KW - HIV-1/genetics

KW - Heterosexuality

KW - High-Throughput Nucleotide Sequencing

KW - Human Immunodeficiency Virus Proteins/genetics

KW - Humans

KW - Male

KW - Models, Statistical

KW - Molecular Sequence Data

KW - Point Mutation

KW - Risk Factors

KW - Selection, Genetic

KW - Viral Load

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DO - 10.1126/science.1254031

M3 - Article

C2 - 25013080

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VL - 345

SP - 1254031

JO - Science (New York, N.Y.)

JF - Science (New York, N.Y.)

IS - 6193

ER -

HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck

Abstract

Bibliographical note

UN SDGs

Keywords

PubMed: MeSH publication types

Publisher link

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