HIV Restriction Factors and Their Ambiguous Role during Infection

A. A. Zotova; A. A. Atemasova; A. V. Filatov; D. V. Mazurov

doi:10.1134/S0026898419020174

HIV Restriction Factors and Their Ambiguous Role during Infection

A. A. Zotova, A. A. Atemasova, A. V. Filatov, D. V. Mazurov

Research output: Contribution to journal › Review article › peer-review

Abstract

Currently, more than 37 million individuals worldwide are infected with the human immunodeficiency virus (HIV). Antiretroviral therapy may control the viral infection but is incapable of eradicating it. It is important to understand how cells respond to HIV-1 infection and what cellular factors are involved in this process to develop novel classes of antiviral drugs. This review summarizes the current understanding of the HIV restriction mechanism. We discuss the ambiguous role of HIV restriction factors in viral infection and counteraction mediated by HIV-1 accessory proteins.

Original language	English (US)
Pages (from-to)	240-255
Number of pages	16
Journal	Molekuliarnaia biologiia
Volume	53
Issue number	2
DOIs	https://doi.org/10.1134/S0026898419020174
State	Published - Mar 1 2019
Externally published	Yes

Keywords

HIV
HIV accessory proteins
ISGs
restriction factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1134/S0026898419020174

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title = "HIV Restriction Factors and Their Ambiguous Role during Infection",

abstract = "Currently, more than 37 million individuals worldwide are infected with the human immunodeficiency virus (HIV). Antiretroviral therapy may control the viral infection but is incapable of eradicating it. It is important to understand how cells respond to HIV-1 infection and what cellular factors are involved in this process to develop novel classes of antiviral drugs. This review summarizes the current understanding of the HIV restriction mechanism. We discuss the ambiguous role of HIV restriction factors in viral infection and counteraction mediated by HIV-1 accessory proteins.",

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TY - JOUR

T1 - HIV Restriction Factors and Their Ambiguous Role during Infection

AU - Zotova, A. A.

AU - Atemasova, A. A.

AU - Filatov, A. V.

AU - Mazurov, D. V.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Currently, more than 37 million individuals worldwide are infected with the human immunodeficiency virus (HIV). Antiretroviral therapy may control the viral infection but is incapable of eradicating it. It is important to understand how cells respond to HIV-1 infection and what cellular factors are involved in this process to develop novel classes of antiviral drugs. This review summarizes the current understanding of the HIV restriction mechanism. We discuss the ambiguous role of HIV restriction factors in viral infection and counteraction mediated by HIV-1 accessory proteins.

AB - Currently, more than 37 million individuals worldwide are infected with the human immunodeficiency virus (HIV). Antiretroviral therapy may control the viral infection but is incapable of eradicating it. It is important to understand how cells respond to HIV-1 infection and what cellular factors are involved in this process to develop novel classes of antiviral drugs. This review summarizes the current understanding of the HIV restriction mechanism. We discuss the ambiguous role of HIV restriction factors in viral infection and counteraction mediated by HIV-1 accessory proteins.

KW - HIV

KW - HIV accessory proteins

KW - ISGs

KW - restriction factors

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M3 - Review article

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SN - 0026-8984

VL - 53

SP - 240

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JO - Molekuliarnaia biologiia

JF - Molekuliarnaia biologiia

IS - 2

ER -

HIV Restriction Factors and Their Ambiguous Role during Infection

Abstract

Keywords

UN SDGs

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