HIV Restriction Factors and Their Ambiguous Role during Infection

A. A. Zotova; A. A. Atemasova; A. V. Filatov; D. V. Mazurov

doi:10.1134/S0026893319020171

HIV Restriction Factors and Their Ambiguous Role during Infection

A. A. Zotova, A. A. Atemasova, A. V. Filatov, D. V. Mazurov

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Currently, more than 37 million individuals worldwide are infected with the human immunodeficiency virus (HIV). Antiretroviral therapy may control the viral infection but is incapable of eradicating it. It is important to understand how cells respond to HIV-1 infection and what cellular factors are involved in this process to develop novel classes of antiviral drugs. This review summarizes the current understanding of the HIV restriction mechanism. We discuss the ambiguous role of HIV restriction factors in viral infection and counteraction mediated by HIV-1 accessory proteins.

Original language	English (US)
Pages (from-to)	212-226
Number of pages	15
Journal	Molecular Biology
Volume	53
Issue number	2
DOIs	https://doi.org/10.1134/S0026893319020171
State	Published - Mar 1 2019
Externally published	Yes

Bibliographical note

Funding Information:
ACKNOWLEDGMENTS The work was supported by the Russian Science Foundation (Searching New HIV-1 Restriction Factors Affecting Viral Replication at Cell-to-Cell Transmission Settings via GeCKO Library Screening, project no. 15-15-00135) and the Russian Foundation for Basic Research (Role of KPNA1, CD82 and Other Cellular Factors Involved in HTLV-1 Replication and Selected after GeCKO Library Screening, project no. 18-34-00712).

Publisher Copyright:
© 2019, Pleiades Publishing, Inc.

Keywords

HIV
HIV accessory proteins
ISGs
restriction factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1134/S0026893319020171

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title = "HIV Restriction Factors and Their Ambiguous Role during Infection",

abstract = "Currently, more than 37 million individuals worldwide are infected with the human immunodeficiency virus (HIV). Antiretroviral therapy may control the viral infection but is incapable of eradicating it. It is important to understand how cells respond to HIV-1 infection and what cellular factors are involved in this process to develop novel classes of antiviral drugs. This review summarizes the current understanding of the HIV restriction mechanism. We discuss the ambiguous role of HIV restriction factors in viral infection and counteraction mediated by HIV-1 accessory proteins.",

keywords = "HIV, HIV accessory proteins, ISGs, restriction factors",

author = "Zotova, {A. A.} and Atemasova, {A. A.} and Filatov, {A. V.} and Mazurov, {D. V.}",

note = "Funding Information: ACKNOWLEDGMENTS The work was supported by the Russian Science Foundation (Searching New HIV-1 Restriction Factors Affecting Viral Replication at Cell-to-Cell Transmission Settings via GeCKO Library Screening, project no. 15-15-00135) and the Russian Foundation for Basic Research (Role of KPNA1, CD82 and Other Cellular Factors Involved in HTLV-1 Replication and Selected after GeCKO Library Screening, project no. 18-34-00712). Publisher Copyright: {\textcopyright} 2019, Pleiades Publishing, Inc.",

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doi = "10.1134/S0026893319020171",

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T1 - HIV Restriction Factors and Their Ambiguous Role during Infection

AU - Zotova, A. A.

AU - Atemasova, A. A.

AU - Filatov, A. V.

AU - Mazurov, D. V.

N1 - Funding Information: ACKNOWLEDGMENTS The work was supported by the Russian Science Foundation (Searching New HIV-1 Restriction Factors Affecting Viral Replication at Cell-to-Cell Transmission Settings via GeCKO Library Screening, project no. 15-15-00135) and the Russian Foundation for Basic Research (Role of KPNA1, CD82 and Other Cellular Factors Involved in HTLV-1 Replication and Selected after GeCKO Library Screening, project no. 18-34-00712). Publisher Copyright: © 2019, Pleiades Publishing, Inc.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Currently, more than 37 million individuals worldwide are infected with the human immunodeficiency virus (HIV). Antiretroviral therapy may control the viral infection but is incapable of eradicating it. It is important to understand how cells respond to HIV-1 infection and what cellular factors are involved in this process to develop novel classes of antiviral drugs. This review summarizes the current understanding of the HIV restriction mechanism. We discuss the ambiguous role of HIV restriction factors in viral infection and counteraction mediated by HIV-1 accessory proteins.

AB - Currently, more than 37 million individuals worldwide are infected with the human immunodeficiency virus (HIV). Antiretroviral therapy may control the viral infection but is incapable of eradicating it. It is important to understand how cells respond to HIV-1 infection and what cellular factors are involved in this process to develop novel classes of antiviral drugs. This review summarizes the current understanding of the HIV restriction mechanism. We discuss the ambiguous role of HIV restriction factors in viral infection and counteraction mediated by HIV-1 accessory proteins.

KW - HIV

KW - HIV accessory proteins

KW - ISGs

KW - restriction factors

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UR - http://www.scopus.com/inward/citedby.url?scp=85066127691&partnerID=8YFLogxK

U2 - 10.1134/S0026893319020171

DO - 10.1134/S0026893319020171

M3 - Review article

AN - SCOPUS:85066127691

SN - 0026-8933

VL - 53

SP - 212

EP - 226

JO - Molecular Biology

JF - Molecular Biology

IS - 2

ER -

HIV Restriction Factors and Their Ambiguous Role during Infection

Abstract

Bibliographical note

Keywords

UN SDGs

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