TY - JOUR
T1 - HIV-1 treatment as prevention
T2 - The good, the bad, and the challenges
AU - Smith, Kumi
AU - Powers, Kimberly A.
AU - Kashuba, Angela D.M.
AU - Cohen, Myron S.
PY - 2011/7
Y1 - 2011/7
N2 - PURPOSE OF REVIEW: This work focuses on the use of antiretroviral agents to prevent the sexual transmission of HIV-1. RECENT FINDINGS: Two randomized clinical trials demonstrated that antiretroviral agents provided before exposure to HIV-1 offer substantial protection, ostensibly directly proportional to the concentration of antiretroviral therapy (ART) in the genital secretions. Intense focus on the use of HIV treatment as prevention has led to publication of modeling exercises, ecological studies, and observational studies, most of which support the potential benefits of ART. However, the logistical requirements for successful use of ART for prevention are considerable. SUMMARY: ART will serve as a cornerstone of combination prevention of HIV-1. Continued research will be essential to measure anticipated benefits and to detect implementation barriers and untoward consequences of such a program, especially increases in primary ART resistance.
AB - PURPOSE OF REVIEW: This work focuses on the use of antiretroviral agents to prevent the sexual transmission of HIV-1. RECENT FINDINGS: Two randomized clinical trials demonstrated that antiretroviral agents provided before exposure to HIV-1 offer substantial protection, ostensibly directly proportional to the concentration of antiretroviral therapy (ART) in the genital secretions. Intense focus on the use of HIV treatment as prevention has led to publication of modeling exercises, ecological studies, and observational studies, most of which support the potential benefits of ART. However, the logistical requirements for successful use of ART for prevention are considerable. SUMMARY: ART will serve as a cornerstone of combination prevention of HIV-1. Continued research will be essential to measure anticipated benefits and to detect implementation barriers and untoward consequences of such a program, especially increases in primary ART resistance.
KW - antiretroviral therapy
KW - pre-exposure prophylaxis
KW - prevention
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UR - http://www.scopus.com/inward/citedby.url?scp=79959371227&partnerID=8YFLogxK
U2 - 10.1097/COH.0b013e32834788e7
DO - 10.1097/COH.0b013e32834788e7
M3 - Review article
C2 - 21646878
AN - SCOPUS:79959371227
SN - 1746-630X
VL - 6
SP - 315
EP - 325
JO - Current Opinion in HIV and AIDS
JF - Current Opinion in HIV and AIDS
IS - 4
ER -
