History, applications, and mechanisms of deep brain stimulation

Svjetlana Miocinovic, Suvarchala Somayajula, Shilpa Chitnis, Jerrold L. Vitek

Research output: Contribution to journalReview articlepeer-review

384 Scopus citations


Deep brain stimulation (DBS) is an effective surgical treatment for medication-refractory hypokinetic and hyperkinetic movement disorders, and it is being explored for a variety of other neurological and psychiatric diseases. Deep brain stimulation has been Food and Drug Administration-approved for essential tremor and Parkinson disease and has a humanitarian device exemption for dystonia and obsessive-compulsive disorder. Neurostimulation is the fruit of decades of both technical and scientific advances in the field of basic neuroscience and functional neurosurgery. Despite the clinical success of DBS, the therapeutic mechanism of DBS remains under debate. Our objective is to provide a comprehensive review of DBS focusing on movement disorders, including the historical evolution of the technique, applications and outcomes with an overview of the most pertinent literature, current views on mechanisms of stimulation, and description of hardware and programming techniques. We conclude with a discussion of future developments in neurostimulation.

Original languageEnglish (US)
Pages (from-to)163-171
Number of pages9
JournalJAMA Neurology
Issue number2
StatePublished - Feb 2013


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