Histoplasmosis among hospitalized febrile patients in northern Tanzania

Sarah M. Lofgren, Emily J. Kirsch, Venance P. Maro, Anne B. Morrissey, Levina J. Msuya, Grace D. Kinabo, Wilbrod Saganda, Helmut C. Diefenthal, Habib O. Ramadhani, L. Joseph Wheat, John A. Crump

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Histoplasmosis may be common in East Africa but the diagnosis is rarely confirmed. We report 9 (0.9%) cases of probable histoplasmosis retrospectively identified among 970 febrile inpatients studied in northern Tanzania. Median (range) age was 31 (6, 44) years, 6 (67%) were female, 6 (67%) HIV-infected; 7 (78%) were clinically diagnosed with tuberculosis or bacterial pneumonia. Histoplasmosis is an important cause of febrile illness in Tanzania but is rarely considered in the differential diagnosis. Increased clinician awareness and availability of reliable diagnostic tests may improve patient outcomes.

Original languageEnglish (US)
Pages (from-to)504-507
Number of pages4
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Issue number8
StatePublished - Aug 2012

Bibliographical note

Funding Information:
This research was supported by an International Studies on AIDS Associated Co-infections (ISAAC) award, a United States National Institutes of Health (NIH) funded program (U01 AI062563). Authors received support from NIH awards ISAAC (ABM, VPM, LJM, GDK, HOR, JAC); AIDS International Training and Research Program D43 PA-03-018 (ABM, VPM, HOR, JAC); the Duke Clinical Trials Unit and Clinical Research Sites U01 AI069484 (VPM, JAC), the Duke Center for AIDS Research P30 AI 64518 (L-YY, S-CC); the Center for HIV/AIDS Vaccine Immunology U01 AI067854 (JAC); and the Hubert-Yeargan Center for Global Health at Duke University (SML).


  • Africa
  • HIV
  • Histoplasmosis
  • Tanzania
  • Tuberculosis


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