Histopathology of mixed anaerobic intraabdominal infection in mice

R. E. McCallum, M. D. Rohrer, R. Urbaschek, B. Urbaschek

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

This study characterized acute peritonitis and chronic abscess formation resulting from experimental mixed anaerobic infection with Bacteroides melaninogenicus and Fusobacterium necrophorum. At intervals after infection liver and spleen samples were obtained, fixed, and processed for histological examination. An acute to chronic infection progressed in mice infected with this mixture of anaerobic bacteria, whereas, no infection resulted when either organism was injected alone. Acute inflammatory cell infiltrates were noted in tissue samples at 12 h postinfection. Small, discrete areas of liver cell necrosis with neutrophilic infiltrates were observed as early as 24 h. By 48 h after infection the liver parenchyma was infiltrated with both acute and chronic inflammatory cells, with moderate to severe hepatocyte degeneration recognized at 72 h. Large intrahepatic abscesses were present in the subphrenic (upper lobe) area 2 to 6 weeks after experimental infection.

Original languageEnglish (US)
Pages (from-to)702-704
Number of pages3
JournalKlinische Wochenschrift
Volume60
Issue number14
DOIs
StatePublished - Jul 1 1982

Keywords

  • Bacteroides melaninogenicus
  • Fusobacterium necrophorum
  • Histopathology of mixed anaerobic infections
  • Intrahepatic abscesses
  • Peritonitis

Fingerprint Dive into the research topics of 'Histopathology of mixed anaerobic intraabdominal infection in mice'. Together they form a unique fingerprint.

Cite this