Histopathologic changes induced by serotype II infectious bursal disease virus in specific-pathogen-free chickens.

V. Sivanandan, J. Sasipreeyajan, D. A. Halvorson, J. A. Newman

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Specific-pathogen-free (SPF) chickens were infected with infectious bursal disease virus (IBDV) serotype II (turkey, Missouri isolate) at 1 day or 4 weeks of age. Chickens infected at 1 day had small bursas 3 weeks postinfection (PI). Bursas were necrotic and inflamed through 1 week PI. Post-necrotic atrophy of the bursas was marked at 3 weeks PI, and plasma cells in the Harderian gland were depleted. Chickens infected at 4 weeks had slightly enlarged spleens with small gray foci on the surface at 1 week PI. The bursas had massive necrosis and hemorrhages on the mucosal surface and had gelatinous yellowish transudate covering the serosal surface; some bursas were gray. Bursas were smaller than normal through the end of the experiment (4 1/2 weeks PI). At 1 week PI, histologic lesions were multifocal lymphoid necrosis of spleens and necrotic inflammation of the bursas. Post-necrotic atrophy of the bursas was found 2 weeks PI through the end of the experiment. Compared with uninfected controls, infected chickens had significantly more pyroninophilic blast cells in the spleen at 1 week PI and the bursas at 4 1/2 weeks PI. Plasma cells in the Harderian glands of this infected group were depleted as well.

Original languageEnglish (US)
Pages (from-to)709-715
Number of pages7
JournalAvian Diseases
Volume30
Issue number4
DOIs
StatePublished - Jan 1 1986

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