Histopathologic and immunohistochemical features of disseminated cutaneous hemophagocytic histiocytic sarcoma in a maltese dog

H. Y. Lim; Y. G. Jang; J. H. Ju; J. I. Shin; H. W. Kim; N. H. Kim; K. S. Im; S. M. Lee; J. H. Sur

Histopathologic and immunohistochemical features of disseminated cutaneous hemophagocytic histiocytic sarcoma in a maltese dog

H. Y. Lim, Y. G. Jang, J. H. Ju, J. I. Shin, H. W. Kim, N. H. Kim, K. S. Im, S. M. Lee, J. H. Sur

Veterinary Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

A 14-year-old, spayed female, Maltese with multiple nodular skin lesions was presented to a local animal hospital. The nodules were infiltrated by discrete round to polygonal neoplastic cells with large nuclei. Cells having phagocytic activities and multinucleated cells were also present. Immunohistochemically, neoplastic cells were positive for vimentin, S100, lysozyme and CD18 and negative for pancytokeratin, CD3, CD79α, and CD138. Considering histopathologic and immunohistochemical features, the tumor was diagnosed as disseminated cutaneous hemophagocytichistiocytic sarcoma. This is the first report of this disease in a Maltese dog.

Original language	English (US)
Pages (from-to)	127-130
Number of pages	4
Journal	Pakistan Veterinary Journal
Volume	35
Issue number	1
State	Published - 2015

Bibliographical note

Publisher Copyright:
© 2014 PVJ.

Keywords

CD18
Dogs
Histiocytic sarcoma
Immunohistochemistry
Neoplasms

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title = "Histopathologic and immunohistochemical features of disseminated cutaneous hemophagocytic histiocytic sarcoma in a maltese dog",

abstract = "A 14-year-old, spayed female, Maltese with multiple nodular skin lesions was presented to a local animal hospital. The nodules were infiltrated by discrete round to polygonal neoplastic cells with large nuclei. Cells having phagocytic activities and multinucleated cells were also present. Immunohistochemically, neoplastic cells were positive for vimentin, S100, lysozyme and CD18 and negative for pancytokeratin, CD3, CD79α, and CD138. Considering histopathologic and immunohistochemical features, the tumor was diagnosed as disseminated cutaneous hemophagocytichistiocytic sarcoma. This is the first report of this disease in a Maltese dog.",

keywords = "CD18, Dogs, Histiocytic sarcoma, Immunohistochemistry, Neoplasms",

author = "Lim, {H. Y.} and Jang, {Y. G.} and Ju, {J. H.} and Shin, {J. I.} and Kim, {H. W.} and Kim, {N. H.} and Im, {K. S.} and Lee, {S. M.} and Sur, {J. H.}",

note = "Publisher Copyright: {\textcopyright} 2014 PVJ.",

year = "2015",

language = "English (US)",

volume = "35",

pages = "127--130",

journal = "Pakistan Veterinary Journal",

issn = "0253-8318",

publisher = "Faculty Of Veterinary Science, University Of Agriculture",

number = "1",

}

TY - JOUR

T1 - Histopathologic and immunohistochemical features of disseminated cutaneous hemophagocytic histiocytic sarcoma in a maltese dog

AU - Lim, H. Y.

AU - Jang, Y. G.

AU - Ju, J. H.

AU - Shin, J. I.

AU - Kim, H. W.

AU - Kim, N. H.

AU - Im, K. S.

AU - Lee, S. M.

AU - Sur, J. H.

PY - 2015

Y1 - 2015

N2 - A 14-year-old, spayed female, Maltese with multiple nodular skin lesions was presented to a local animal hospital. The nodules were infiltrated by discrete round to polygonal neoplastic cells with large nuclei. Cells having phagocytic activities and multinucleated cells were also present. Immunohistochemically, neoplastic cells were positive for vimentin, S100, lysozyme and CD18 and negative for pancytokeratin, CD3, CD79α, and CD138. Considering histopathologic and immunohistochemical features, the tumor was diagnosed as disseminated cutaneous hemophagocytichistiocytic sarcoma. This is the first report of this disease in a Maltese dog.

AB - A 14-year-old, spayed female, Maltese with multiple nodular skin lesions was presented to a local animal hospital. The nodules were infiltrated by discrete round to polygonal neoplastic cells with large nuclei. Cells having phagocytic activities and multinucleated cells were also present. Immunohistochemically, neoplastic cells were positive for vimentin, S100, lysozyme and CD18 and negative for pancytokeratin, CD3, CD79α, and CD138. Considering histopathologic and immunohistochemical features, the tumor was diagnosed as disseminated cutaneous hemophagocytichistiocytic sarcoma. This is the first report of this disease in a Maltese dog.

KW - CD18

KW - Dogs

KW - Histiocytic sarcoma

KW - Immunohistochemistry

KW - Neoplasms

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UR - http://www.scopus.com/inward/citedby.url?scp=84920865875&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84920865875

SN - 0253-8318

VL - 35

SP - 127

EP - 130

JO - Pakistan Veterinary Journal

JF - Pakistan Veterinary Journal

IS - 1

ER -

Histopathologic and immunohistochemical features of disseminated cutaneous hemophagocytic histiocytic sarcoma in a maltese dog

Abstract

Bibliographical note

Keywords

UN SDGs

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