Histone H2AX and the small RNA pathway modulate both non-homologous end-joining and homologous recombination in plants

Yiping Qi; Yong Zhang; Joshua A. Baller; Daniel F Voytas

doi:10.1016/j.mrfmmm.2015.12.002

Histone H2AX and the small RNA pathway modulate both non-homologous end-joining and homologous recombination in plants

Yiping Qi, Yong Zhang, Joshua A. Baller, Daniel F Voytas

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Using a zinc finger nuclease (ZFN) that creates a site-specific DNA double-strand break (DSB) at the endogenous ADH1 locus, we provide genetic evidence that histone H2AX and DSB-induced small RNAs modulate DNA repair by both non-homologous end-joining (NHEJ) and homologous recombination (HR) in the model plant Arabidopsis thaliana.

Original language	English (US)
Pages (from-to)	9-14
Number of pages	6
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	783
DOIs	https://doi.org/10.1016/j.mrfmmm.2015.12.002
State	Published - Jan 1 2016

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Publisher Copyright:
© 2015 Published by Elsevier B.V.

Keywords

Arabidopsis thaliana
DNA double-strand break (DSB) repair
H2AX
Small RNA
Zinc finger nuclease (ZFN)

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10.1016/j.mrfmmm.2015.12.002

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title = "Histone H2AX and the small RNA pathway modulate both non-homologous end-joining and homologous recombination in plants",

abstract = "Using a zinc finger nuclease (ZFN) that creates a site-specific DNA double-strand break (DSB) at the endogenous ADH1 locus, we provide genetic evidence that histone H2AX and DSB-induced small RNAs modulate DNA repair by both non-homologous end-joining (NHEJ) and homologous recombination (HR) in the model plant Arabidopsis thaliana.",

keywords = "Arabidopsis thaliana, DNA double-strand break (DSB) repair, H2AX, Small RNA, Zinc finger nuclease (ZFN)",

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doi = "10.1016/j.mrfmmm.2015.12.002",

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T1 - Histone H2AX and the small RNA pathway modulate both non-homologous end-joining and homologous recombination in plants

AU - Qi, Yiping

AU - Zhang, Yong

AU - Baller, Joshua A.

AU - Voytas, Daniel F

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Using a zinc finger nuclease (ZFN) that creates a site-specific DNA double-strand break (DSB) at the endogenous ADH1 locus, we provide genetic evidence that histone H2AX and DSB-induced small RNAs modulate DNA repair by both non-homologous end-joining (NHEJ) and homologous recombination (HR) in the model plant Arabidopsis thaliana.

AB - Using a zinc finger nuclease (ZFN) that creates a site-specific DNA double-strand break (DSB) at the endogenous ADH1 locus, we provide genetic evidence that histone H2AX and DSB-induced small RNAs modulate DNA repair by both non-homologous end-joining (NHEJ) and homologous recombination (HR) in the model plant Arabidopsis thaliana.

KW - Arabidopsis thaliana

KW - DNA double-strand break (DSB) repair

KW - H2AX

KW - Small RNA

KW - Zinc finger nuclease (ZFN)

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DO - 10.1016/j.mrfmmm.2015.12.002

M3 - Article

C2 - 26687994

AN - SCOPUS:84949521482

SN - 0027-5107

VL - 783

SP - 9

EP - 14

JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

ER -

Histone H2AX and the small RNA pathway modulate both non-homologous end-joining and homologous recombination in plants

Abstract

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