Histone deacetylase 3 suppression increases PH domain and leucine-rich repeat phosphatase (Phlpp)1 expression in chondrocytes to suppress Akt signaling and matrix secretion

Keyphrases

• Phosphatase 100%
• PH Domain 100%
• Chondrocytes 100%
• AKT Pathway 100%
• Histone Deacetylase 3 (HDAC3) 100%
• Leucine-rich Repeat 100%
• Mammalian Target of Rapamycin (mTOR) 27%
• Histone Deacetylase Inhibitor (HDACi) 18%
• Hypertrophy 18%
• Phosphorylation 18%
• P70S6K 18%
• Gene Expression 9%
• Glycosaminoglycans 9%
• Osteoblast 9%
• Cellular Processes 9%
• Osteopontin 9%
• Articular Chondrocytes 9%
• Chondrocyte Differentiation 9%
• Chromatin 9%
• Akt Phosphorylation 9%
• Promoter Region 9%
• Constitutively Active 9%
• Smad 9%
• Gene Expression Level 9%
• Longitudinal Growth 9%
• Osteopenia 9%
• Matrix Production 9%
• Conditional Deletion 9%
• Extracellular Matrix Deposition 9%
• Aggrecan 9%
• Chondrocyte Hypertrophy 9%
• PI3K-AKT-mTOR Pathway 9%
• Chondroprogenitor Cells 9%
• Primary Chondrocytes 9%
• Growth Plate Chondrocyte 9%
• Matrix Gene Expression 9%
• Osteochondroprogenitors 9%
• Matrix Extracellular Phosphoglycoprotein 9%

Biochemistry, Genetics and Molecular Biology

• Phosphatase 100%
• Leucine-Rich Repeat 100%
• Secretion (Process) 100%
• Pleckstrin Homology Domain 100%
• Akt Signaling 100%
• Chondrocyte 100%
• HDAC3 100%
• Mammalian Target of Rapamycin 33%
• Glycosaminoglycan 8%
• Osteoblast 8%
• Gene Expression 8%
• Mouse 8%
• Maturation 8%
• Promoter Region 8%
• Gene Expression Level 8%
• Phosphotransferase 8%
• Kinase 8%
• Osteopontin 8%
• Aggrecan 8%