Histidyl-proline diketopiperazine decreases food intake in rats

John E. Morley; Allen S. Levine; Chandan Prasad

doi:10.1016/0006-8993(81)90930-6

Histidyl-proline diketopiperazine decreases food intake in rats

John E. Morley, Allen S. Levine, Chandan Prasad

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Abstract

Histidyl-proline diketopiperazine was found to suppress food intake during stress-induced eating (10^-6-10^-8 mol), starvation-induced eating (10^-8 mol) and over an 8 h period of spontaneous eating (10^-8 mol). In contrast, other cyclic piperzines failed to alter food ingestion. The suppressive effect of histidyl-proline diketopiperazine was antagonized by the enkephalin analogue, d-Ala-Met-enkephalin, in equimolar concentrations.

Original language	English (US)
Pages (from-to)	475-478
Number of pages	4
Journal	Brain Research
Volume	210
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(81)90930-6
State	Published - Apr 6 1981

Keywords

enkephalin analog
food intake
histidyl-proline diketopiperazine

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10.1016/0006-8993(81)90930-6

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abstract = "Histidyl-proline diketopiperazine was found to suppress food intake during stress-induced eating (10-6-10-8 mol), starvation-induced eating (10-8 mol) and over an 8 h period of spontaneous eating (10-8 mol). In contrast, other cyclic piperzines failed to alter food ingestion. The suppressive effect of histidyl-proline diketopiperazine was antagonized by the enkephalin analogue, d-Ala-Met-enkephalin, in equimolar concentrations.",

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N2 - Histidyl-proline diketopiperazine was found to suppress food intake during stress-induced eating (10-6-10-8 mol), starvation-induced eating (10-8 mol) and over an 8 h period of spontaneous eating (10-8 mol). In contrast, other cyclic piperzines failed to alter food ingestion. The suppressive effect of histidyl-proline diketopiperazine was antagonized by the enkephalin analogue, d-Ala-Met-enkephalin, in equimolar concentrations.

AB - Histidyl-proline diketopiperazine was found to suppress food intake during stress-induced eating (10-6-10-8 mol), starvation-induced eating (10-8 mol) and over an 8 h period of spontaneous eating (10-8 mol). In contrast, other cyclic piperzines failed to alter food ingestion. The suppressive effect of histidyl-proline diketopiperazine was antagonized by the enkephalin analogue, d-Ala-Met-enkephalin, in equimolar concentrations.

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KW - food intake

KW - histidyl-proline diketopiperazine

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ER -

Histidyl-proline diketopiperazine decreases food intake in rats

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