Histidyl-proline diketopiperazine was found to suppress food intake during stress-induced eating (10-6-10-8 mol), starvation-induced eating (10-8 mol) and over an 8 h period of spontaneous eating (10-8 mol). In contrast, other cyclic piperzines failed to alter food ingestion. The suppressive effect of histidyl-proline diketopiperazine was antagonized by the enkephalin analogue, d-Ala-Met-enkephalin, in equimolar concentrations.
- enkephalin analog
- food intake
- histidyl-proline diketopiperazine