Histidyl-proline diketopiperazine decreases food intake in rats

John E. Morley, Allen S. Levine, Chandan Prasad

Research output: Contribution to journalArticlepeer-review

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Histidyl-proline diketopiperazine was found to suppress food intake during stress-induced eating (10-6-10-8 mol), starvation-induced eating (10-8 mol) and over an 8 h period of spontaneous eating (10-8 mol). In contrast, other cyclic piperzines failed to alter food ingestion. The suppressive effect of histidyl-proline diketopiperazine was antagonized by the enkephalin analogue, d-Ala-Met-enkephalin, in equimolar concentrations.

Original languageEnglish (US)
Pages (from-to)475-478
Number of pages4
JournalBrain Research
Issue number1-2
StatePublished - Apr 6 1981


  • enkephalin analog
  • food intake
  • histidyl-proline diketopiperazine


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