Hippocampal sharp waves and reactivation during awake states depend on repeated sequential experience

Jadin C. Jackson, Adam Johnson, A. David Redish

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

Hippocampal firing patterns during behavior are reactivated during rest and subsequent slow-wave sleep. These reactivations occur during transient local field potential (LFP) events, termed sharp waves. Theories of hippocampal processing suggest that sharp waves arise from strengthened plasticity, and that the strengthened plasticity depends on repeated cofiring of pyramidal cells. We tested these predictions by recording neural ensembles and LFPs from rats running tasks requiring different levels of behavioral repetition. The number of sharp waves emitted increased during sessions with more regular behaviors. Reactivation became more similar to behavioral firing patterns across the session. This enhanced reactivation also depended on the regularity of the behavior. Additional studies in CA3 and CA1 found that the number of sharp waves emitted also increased in CA3 recordings as well as CA1, but that the time courses were different between the two structures.

Original languageEnglish (US)
Pages (from-to)12415-12426
Number of pages12
JournalJournal of Neuroscience
Volume26
Issue number48
DOIs
StatePublished - Nov 29 2006

Keywords

  • CA1
  • CA3
  • Hippocampus
  • Local field potential
  • Neural ensemble
  • Place cell
  • Sharp wave

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