Hippocampal neuronal loss and regional hypometabolism in temporal lobe epilepsy

Thomas R. Henry; Thomas L. Babb; Jerome Engel; John C. Mazziotta; Michael E. Phelps; Paul H. Crandall

doi:10.1002/ana.410360620

Hippocampal neuronal loss and regional hypometabolism in temporal lobe epilepsy

Thomas R. Henry
, Thomas L. Babb
, Jerome Engel
, John C. Mazziotta
, Michael E. Phelps
, Paul H. Crandall

Neurology

Research output: Contribution to journal › Article › peer-review

123 Scopus citations

Abstract

The pathophysiology of widespread interictal hypometabolism in temporal lobe epilepsy is unknown but might reflect neuronal loss and diaschisis. We found no significant correlation between any cortical region's metabolism on preoperative {¹⁸F} fluorodeoxyglucose positron emission tomography and neuronal density of resected hippocampi in 40 patients. We conclude that hippocampal neuronal loss and diaschisis cannot account for the regional interictal hypometabolism of temporal lobe epilepsy.

Original language	English (US)
Pages (from-to)	925-927
Number of pages	3
Journal	Annals of Neurology
Volume	36
Issue number	6
DOIs	https://doi.org/10.1002/ana.410360620
State	Published - Dec 1994

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10.1002/ana.410360620

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abstract = "The pathophysiology of widespread interictal hypometabolism in temporal lobe epilepsy is unknown but might reflect neuronal loss and diaschisis. We found no significant correlation between any cortical region's metabolism on preoperative \{18F\} fluorodeoxyglucose positron emission tomography and neuronal density of resected hippocampi in 40 patients. We conclude that hippocampal neuronal loss and diaschisis cannot account for the regional interictal hypometabolism of temporal lobe epilepsy.",

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AU - Henry, Thomas R.

AU - Babb, Thomas L.

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AU - Phelps, Michael E.

AU - Crandall, Paul H.

PY - 1994/12

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Hippocampal neuronal loss and regional hypometabolism in temporal lobe epilepsy

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