Hippocampal neuronal loss and regional hypometabolism in temporal lobe epilepsy

Thomas R. Henry, Thomas L. Babb, Jerome Engel, John C. Mazziotta, Michael E. Phelps, Paul H. Crandall

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113 Scopus citations

Abstract

The pathophysiology of widespread interictal hypometabolism in temporal lobe epilepsy is unknown but might reflect neuronal loss and diaschisis. We found no significant correlation between any cortical region's metabolism on preoperative {18F} fluorodeoxyglucose positron emission tomography and neuronal density of resected hippocampi in 40 patients. We conclude that hippocampal neuronal loss and diaschisis cannot account for the regional interictal hypometabolism of temporal lobe epilepsy.

Original languageEnglish (US)
Pages (from-to)925-927
Number of pages3
JournalAnnals of Neurology
Volume36
Issue number6
DOIs
StatePublished - Dec 1994

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    Henry, T. R., Babb, T. L., Engel, J., Mazziotta, J. C., Phelps, M. E., & Crandall, P. H. (1994). Hippocampal neuronal loss and regional hypometabolism in temporal lobe epilepsy. Annals of Neurology, 36(6), 925-927. https://doi.org/10.1002/ana.410360620