Hill coefficients of dietary polyphenolic enzyme inhibitiors: Can beneficial health effects of dietary polyphenols be explained by allosteric enzyme denaturing?

Nikolai Kuhnert, Farnoosh Dairpoosh, Rakesh Jaiswal, Marius Matei, Sagar Deshpande, Agnieszka Golon, Hany Nour, Hande Karaköse, Nadim Hourani

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Inspired by a recent article by Prinz, suggesting that Hill coefficients, obtained from four parameter logistic fits to dose-response curves, represent a parameter allowing distinction between a general allosteric denaturing process and real single site enzyme inhibition, Hill coefficients of a number of selected dietary polyphenol enzyme inhibitions were compiled from the available literature. From available literature data, it is apparent that the majority of polyphenol enzyme interactions reported lead to enzyme inhibition via allosteric denaturing rather than single site inhibition as judged by their reported Hill coefficients. The results of these searches are presented and their implications discussed leading to the suggestion of a novel hypothesis for polyphenol biological activity termed the insect swarm hypothesis.

Original languageEnglish (US)
Pages (from-to)109-116
Number of pages8
JournalJournal of Chemical Biology
Volume4
Issue number3
DOIs
StatePublished - Jul 1 2011

Keywords

  • Enzyme inhibition
  • Human diet
  • Polyphenols

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