Highly sensitive fluorescent protein FRET detection using optofluidic lasers

Qiushu Chen, Xingwang Zhang, Yuze Sun, Michael Ritt, Sivaraj Sivaramakrishnan, Xudong Fan

Research output: Contribution to journalArticlepeer-review

107 Scopus citations


We achieved optofluidic protein lasing using genetically encoded fluorescent protein FRET pairs linked by length-tunable peptides. Up to 25-fold reduction in the donor laser emission was observed when the donor and the acceptor were brought to close proximity, as compared to only 17% reduction in the donor emission using the conventional FRET detection. Our work opens a door to a broad range of applications in studying protein-protein interactions and protein-drug interactions.

Original languageEnglish (US)
Pages (from-to)2679-2681
Number of pages3
JournalLab on a chip
Issue number14
StatePublished - Jul 21 2013


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