Abstract
We achieved optofluidic protein lasing using genetically encoded fluorescent protein FRET pairs linked by length-tunable peptides. Up to 25-fold reduction in the donor laser emission was observed when the donor and the acceptor were brought to close proximity, as compared to only 17% reduction in the donor emission using the conventional FRET detection. Our work opens a door to a broad range of applications in studying protein-protein interactions and protein-drug interactions.
Original language | English (US) |
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Pages (from-to) | 2679-2681 |
Number of pages | 3 |
Journal | Lab on a chip |
Volume | 13 |
Issue number | 14 |
DOIs | |
State | Published - Jul 21 2013 |