Highly Pathogenic Avian Influenza A(H5N1) Virus Clade 2.3.4.4b Infections in Wild Terrestrial Mammals, United States, 2022

Elizabeth J. Elsmo; Arno Wünschmann; Kimberlee B. Beckmen; Liam E. Broughton-Neiswanger; Elizabeth L. Buckles; Jayne Ellis; Scott D. Fitzgerald; Robert Gerlach; Shawna Hawkins; Hon S. Ip; Julia S. Lankton; Erin M. Lemley; Julianna B. Lenoch; Mary L. Killian; Kristina Lantz; Lindsey Long; Roger Maes; Marta Mainenti; Julie Melotti; Megan E. Moriarty; Shotaro Nakagun; Rachel M. Ruden; Valerie Shearn-Bochsler; Danielle Thompson; Mia K. Torchetti; Arnaud J. Van Wettere; Annabel G. Wise; Ailam L. Lim

doi:10.3201/eid2912.230464

Highly Pathogenic Avian Influenza A(H5N1) Virus Clade 2.3.4.4b Infections in Wild Terrestrial Mammals, United States, 2022

Elizabeth J. Elsmo
, Arno Wünschmann
, Kimberlee B. Beckmen
, Liam E. Broughton-Neiswanger
, Elizabeth L. Buckles
, Jayne Ellis
, Scott D. Fitzgerald
, Robert Gerlach
, Shawna Hawkins
, Hon S. Ip
, Julia S. Lankton
, Erin M. Lemley
, Julianna B. Lenoch
, Mary L. Killian
, Kristina Lantz
, Lindsey Long
, Roger Maes
, Marta Mainenti
, Julie Melotti
, Megan E. Moriarty

Shotaro Nakagun, Rachel M. Ruden, Valerie Shearn-Bochsler, Danielle Thompson, Mia K. Torchetti, Arnaud J. Van Wettere, Annabel G. Wise, Ailam L. Lim

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

We describe the pathology of natural infection with highly pathogenic avian influenza A(H5N1) virus of Eurasian lineage Goose/Guangdong clade 2.3.4.4b in 67 wild terrestrial mammals throughout the United States during April 1‒July 21, 2022. Affected mammals include 50 red foxes (Vulpes vulpes), 6 striped skunks (Mephitis mephitis), 4 raccoons (Procyon lotor), 2 bobcats (Lynx rufus), 2 Virginia opossums (Didelphis virginiana), 1 coyote (Canis latrans), 1 fisher (Pekania pennanti), and 1 gray fox (Urocyon cinereoargenteus). Infected mammals showed primarily neurologic signs. Necrotizing meningoencepha-litis, interstitial pneumonia, and myocardial necrosis were the most common lesions; however, species variations in lesion distribution were observed. Genotype analysis of sequences from 48 animals indicates that these cases represent spillover infections from wild birds.

Original language	English (US)
Pages (from-to)	2451-2460
Number of pages	10
Journal	Emerging infectious diseases
Volume	29
Issue number	12
DOIs	https://doi.org/10.3201/eid2912.230464
State	Published - 2023
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2023 Centers for Disease Control and Prevention (CDC). All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.3201/eid2912.230464

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Elsmo, E. J., Wünschmann, A., Beckmen, K. B., Broughton-Neiswanger, L. E., Buckles, E. L., Ellis, J., Fitzgerald, S. D., Gerlach, R., Hawkins, S., Ip, H. S., Lankton, J. S., Lemley, E. M., Lenoch, J. B., Killian, M. L., Lantz, K., Long, L., Maes, R., Mainenti, M., Melotti, J., ... Lim, A. L. (2023). Highly Pathogenic Avian Influenza A(H5N1) Virus Clade 2.3.4.4b Infections in Wild Terrestrial Mammals, United States, 2022. Emerging infectious diseases, 29(12), 2451-2460. https://doi.org/10.3201/eid2912.230464

Elsmo, EJ, Wünschmann, A, Beckmen, KB, Broughton-Neiswanger, LE, Buckles, EL, Ellis, J, Fitzgerald, SD, Gerlach, R, Hawkins, S, Ip, HS, Lankton, JS, Lemley, EM, Lenoch, JB, Killian, ML, Lantz, K, Long, L, Maes, R, Mainenti, M, Melotti, J, Moriarty, ME, Nakagun, S, Ruden, RM, Shearn-Bochsler, V, Thompson, D, Torchetti, MK, Van Wettere, AJ, Wise, AG & Lim, AL 2023, 'Highly Pathogenic Avian Influenza A(H5N1) Virus Clade 2.3.4.4b Infections in Wild Terrestrial Mammals, United States, 2022', Emerging infectious diseases, vol. 29, no. 12, pp. 2451-2460. https://doi.org/10.3201/eid2912.230464

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abstract = "We describe the pathology of natural infection with highly pathogenic avian influenza A(H5N1) virus of Eurasian lineage Goose/Guangdong clade 2.3.4.4b in 67 wild terrestrial mammals throughout the United States during April 1‒July 21, 2022. Affected mammals include 50 red foxes (Vulpes vulpes), 6 striped skunks (Mephitis mephitis), 4 raccoons (Procyon lotor), 2 bobcats (Lynx rufus), 2 Virginia opossums (Didelphis virginiana), 1 coyote (Canis latrans), 1 fisher (Pekania pennanti), and 1 gray fox (Urocyon cinereoargenteus). Infected mammals showed primarily neurologic signs. Necrotizing meningoencepha-litis, interstitial pneumonia, and myocardial necrosis were the most common lesions; however, species variations in lesion distribution were observed. Genotype analysis of sequences from 48 animals indicates that these cases represent spillover infections from wild birds.",

author = "Elsmo, \{Elizabeth J.\} and Arno W{\"u}nschmann and Beckmen, \{Kimberlee B.\} and Broughton-Neiswanger, \{Liam E.\} and Buckles, \{Elizabeth L.\} and Jayne Ellis and Fitzgerald, \{Scott D.\} and Robert Gerlach and Shawna Hawkins and Ip, \{Hon S.\} and Lankton, \{Julia S.\} and Lemley, \{Erin M.\} and Lenoch, \{Julianna B.\} and Killian, \{Mary L.\} and Kristina Lantz and Lindsey Long and Roger Maes and Marta Mainenti and Julie Melotti and Moriarty, \{Megan E.\} and Shotaro Nakagun and Ruden, \{Rachel M.\} and Valerie Shearn-Bochsler and Danielle Thompson and Torchetti, \{Mia K.\} and \{Van Wettere\}, \{Arnaud J.\} and Wise, \{Annabel G.\} and Lim, \{Ailam L.\}",

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AU - Wünschmann, Arno

AU - Beckmen, Kimberlee B.

AU - Broughton-Neiswanger, Liam E.

AU - Buckles, Elizabeth L.

AU - Ellis, Jayne

AU - Fitzgerald, Scott D.

AU - Gerlach, Robert

AU - Hawkins, Shawna

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AU - Lankton, Julia S.

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AU - Moriarty, Megan E.

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AU - Ruden, Rachel M.

AU - Shearn-Bochsler, Valerie

AU - Thompson, Danielle

AU - Torchetti, Mia K.

AU - Van Wettere, Arnaud J.

AU - Wise, Annabel G.

AU - Lim, Ailam L.

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Highly Pathogenic Avian Influenza A(H5N1) Virus Clade 2.3.4.4b Infections in Wild Terrestrial Mammals, United States, 2022

Abstract

Bibliographical note

UN SDGs

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