Highly Effective PQQ Inhibition by Alkynyl and Aryl Mono- and Diiodonium Salts

Paul M. Gallop; Mercedes A. Paz; Rudolf Flückiger; Peter J. Stang; Viktor V. Zhdankin; Rik R. Tykwinski

doi:10.1021/ja00078a007

Highly Effective PQQ Inhibition by Alkynyl and Aryl Mono- and Diiodonium Salts

Paul M. Gallop, Mercedes A. Paz, Rudolf Flückiger, Peter J. Stang, Viktor V. Zhdankin, Rik R. Tykwinski

Chemistry & Biochemistry

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

PQQ (methoxatin), a bis(quinone) tricarboxylic acid, is an organic cofactor in a variety of biological redox processes. It is effectively inhibited on a micromolar scale by alkynyl and aryl monoiodonium salts, whereas bis- (iodonium)triflates 5 and 8 are PQQ inhibitors at nanomolar levels.

Original language	English (US)
Pages (from-to)	11702-11704
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	115
Issue number	25
DOIs	https://doi.org/10.1021/ja00078a007
State	Published - Dec 1 1993

Publisher link

10.1021/ja00078a007

Find It

Find It at U of M Libraries

Cite this

@article{548cc8ad99354672b0320779779bd726,

title = "Highly Effective PQQ Inhibition by Alkynyl and Aryl Mono- and Diiodonium Salts",

abstract = "PQQ (methoxatin), a bis(quinone) tricarboxylic acid, is an organic cofactor in a variety of biological redox processes. It is effectively inhibited on a micromolar scale by alkynyl and aryl monoiodonium salts, whereas bis- (iodonium)triflates 5 and 8 are PQQ inhibitors at nanomolar levels.",

author = "Gallop, {Paul M.} and Paz, {Mercedes A.} and Rudolf Fl{\"u}ckiger and Stang, {Peter J.} and Zhdankin, {Viktor V.} and Tykwinski, {Rik R.}",

year = "1993",

month = dec,

day = "1",

doi = "10.1021/ja00078a007",

language = "English (US)",

volume = "115",

pages = "11702--11704",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "25",

}

TY - JOUR

T1 - Highly Effective PQQ Inhibition by Alkynyl and Aryl Mono- and Diiodonium Salts

AU - Gallop, Paul M.

AU - Paz, Mercedes A.

AU - Flückiger, Rudolf

AU - Stang, Peter J.

AU - Zhdankin, Viktor V.

AU - Tykwinski, Rik R.

PY - 1993/12/1

Y1 - 1993/12/1

N2 - PQQ (methoxatin), a bis(quinone) tricarboxylic acid, is an organic cofactor in a variety of biological redox processes. It is effectively inhibited on a micromolar scale by alkynyl and aryl monoiodonium salts, whereas bis- (iodonium)triflates 5 and 8 are PQQ inhibitors at nanomolar levels.

AB - PQQ (methoxatin), a bis(quinone) tricarboxylic acid, is an organic cofactor in a variety of biological redox processes. It is effectively inhibited on a micromolar scale by alkynyl and aryl monoiodonium salts, whereas bis- (iodonium)triflates 5 and 8 are PQQ inhibitors at nanomolar levels.

UR - http://www.scopus.com/inward/record.url?scp=0001625804&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0001625804&partnerID=8YFLogxK

U2 - 10.1021/ja00078a007

DO - 10.1021/ja00078a007

M3 - Article

AN - SCOPUS:0001625804

SN - 0002-7863

VL - 115

SP - 11702

EP - 11704

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 25

ER -

Highly Effective PQQ Inhibition by Alkynyl and Aryl Mono- and Diiodonium Salts

Abstract

Publisher link

Find It

Other files and links

Fingerprint

Cite this