Highly Effective PQQ Inhibition by Alkynyl and Aryl Mono- and Diiodonium Salts

Paul M. Gallop, Mercedes A. Paz, Rudolf Flückiger, Peter J. Stang, Viktor V. Zhdankin, Rik R. Tykwinski

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

PQQ (methoxatin), a bis(quinone) tricarboxylic acid, is an organic cofactor in a variety of biological redox processes. It is effectively inhibited on a micromolar scale by alkynyl and aryl monoiodonium salts, whereas bis- (iodonium)triflates 5 and 8 are PQQ inhibitors at nanomolar levels.

Original languageEnglish (US)
Pages (from-to)11702-11704
Number of pages3
JournalJournal of the American Chemical Society
Volume115
Issue number25
DOIs
StatePublished - Dec 1 1993

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