Highly-Accelerated High-Resolution Multi-Echo fMRI Using Self-Supervised Physics-Driven Deep Learning Reconstruction

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Functional MRI (fMRI) is a critical tool for visu-alizing neural activities in the brain. fMRI analysis requires comprehensive coverage with high spatiotemporal resolution. To this end, a combination of simultaneous multi-slice imaging and in-plane acceleration is commonly used. However, conventional reconstructions are based on linear methods, leading to noise amplification and aliasing at high accelerations. In particular, the emerging class of multi-echo (ME)-fMRI techniques, which acquire the same imaging location at multiple echo times after a single excitation and offer the potential for further quantification, require higher acceleration rates, beyond what is achievable with conventional methods. In the broader MRI community, deep learning (DL) techniques have been proposed for improved image reconstruction at higher accelerations. While the conventional supervised training paradigms are not applicable to fMRI due to the lack of fully-sampled reference data, we have previously shown that self-supervised DL methods are feasible for high-resolution accelerated fMRI. In this study, we adapt these strategies for ME-fMRI to enable prospective 20-fold acceleration with high-resolution and whole-brain coverage with 3 echoes at 7T. Our network leverages the T_2* correlations between multiple echoes. Results indicate the feasibility of high-resolution 20-fold accelerated whole-brain ME-fMRI, leading to neural activation maps consistent with the expected activation patterns.

Original languageEnglish (US)
Title of host publication2023 IEEE 9th International Workshop on Computational Advances in Multi-Sensor Adaptive Processing, CAMSAP 2023
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages196-200
Number of pages5
ISBN (Electronic)9798350344523
DOIs
StatePublished - 2023
Event9th IEEE International Workshop on Computational Advances in Multi-Sensor Adaptive Processing, CAMSAP 2023 - Herradura, Costa Rica
Duration: Dec 10 2023Dec 13 2023

Publication series

Name2023 IEEE 9th International Workshop on Computational Advances in Multi-Sensor Adaptive Processing, CAMSAP 2023

Conference

Conference9th IEEE International Workshop on Computational Advances in Multi-Sensor Adaptive Processing, CAMSAP 2023
Country/TerritoryCosta Rica
CityHerradura
Period12/10/2312/13/23

Bibliographical note

Publisher Copyright:
© 2023 IEEE.

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