Higher pericardial adiposity is associated with prevalent diabetes: The Coronary Artery Risk Development in Young Adults study

A. C. Alman; D. R. Jacobs; C. E. Lewis; J. K. Snell-Bergeon; M. R. Carnethon; J. G. Terry; D. C. Goff; J. Ding; J. J. Carr

doi:10.1016/j.numecd.2015.12.011

Higher pericardial adiposity is associated with prevalent diabetes: The Coronary Artery Risk Development in Young Adults study

A. C. Alman, D. R. Jacobs, C. E. Lewis, J. K. Snell-Bergeon, M. R. Carnethon, J. G. Terry, D. C. Goff, J. Ding, J. J. Carr

Epidemiology & Community Health

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Background and aims: Pericardial adipose tissue (PAT) is located on both sides of the pericardium. We tested whether PAT was associated with prevalent diabetes at the year 25 exam of the Coronary Artery Risk Development in Young Adults (CARDIA) study. Methods and results: The CARDIA Year 25 exam (2010-2011) included complete data for all covariates on 3107 participants. Prevalent diabetes (n = 436) was defined as high fasting (≥126 mg/dl) or 2-h postload glucose (≥200 mg/dl) or HbA_1c (≥6.5%) or use of diabetes medications. Volume of PAT was measured from computed tomographic scans. Logistic regression was performed to examine the relationship between quartiles of PAT and diabetes. In regression models adjusted for field center, sex, race, age, systolic blood pressure, total cholesterol, log triglycerides, and treatment with blood pressure and cholesterol lowering medication, PAT volume in the 4th quartile was significantly associated with diabetes status after adjustment for BMI (OR 2.57, 95% CI 1.66, 3.98) or visceral adipose tissue (OR 2.08, 95% CI 1.32, 3.29). PAT volume in the 2nd and 3rd quartiles was not significantly associated with diabetes status relative to the first quartile. Conclusions: Metabolically active pericardial adipose tissue is associated with prevalent diabetes only at higher volumes independent of overall obesity.

Original language	English (US)
Pages (from-to)	326-332
Number of pages	7
Journal	Nutrition, Metabolism and Cardiovascular Diseases
Volume	26
Issue number	4
DOIs	https://doi.org/10.1016/j.numecd.2015.12.011
State	Published - Apr 1 2016

Bibliographical note

Funding Information:
This project was funded by the National Heart, Lung, and Blood Institute in part though an investigator initiated grant to Vanderbilt University ( HL098445 ). The Coronary Artery Risk Development in Young Adults Study (CARDIA) is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham ( HHSN268201300025C & HHSN268201300026C ), Northwestern University ( HHSN268201300027C ), University of Minnesota ( HHSN268201300028C ), Kaiser Foundation Research Institute ( HHSN268201300029C ), and Johns Hopkins University School of Medicine ( HHSN268200900041C ). CARDIA is also partially supported by the Intramural Research Program of the National Institute on Aging (NIA) and an intra-agency agreement between NIA and NHLBI ( AG0005 ). This manuscript has been reviewed by CARDIA for scientific content.

Publisher Copyright:
© 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University.

Keywords

Diabetes
Obesity
Pericardial adipose tissue
Visceral adipose tissue

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1016/j.numecd.2015.12.011

http://europepmc.org/articles/pmc4823150

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Alman, A. C., Jacobs, D. R., Lewis, C. E., Snell-Bergeon, J. K., Carnethon, M. R., Terry, J. G., Goff, D. C., Ding, J., & Carr, J. J. (2016). Higher pericardial adiposity is associated with prevalent diabetes: The Coronary Artery Risk Development in Young Adults study. Nutrition, Metabolism and Cardiovascular Diseases, 26(4), 326-332. https://doi.org/10.1016/j.numecd.2015.12.011

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title = "Higher pericardial adiposity is associated with prevalent diabetes: The Coronary Artery Risk Development in Young Adults study",

abstract = "Background and aims: Pericardial adipose tissue (PAT) is located on both sides of the pericardium. We tested whether PAT was associated with prevalent diabetes at the year 25 exam of the Coronary Artery Risk Development in Young Adults (CARDIA) study. Methods and results: The CARDIA Year 25 exam (2010-2011) included complete data for all covariates on 3107 participants. Prevalent diabetes (n = 436) was defined as high fasting (≥126 mg/dl) or 2-h postload glucose (≥200 mg/dl) or HbA1c (≥6.5%) or use of diabetes medications. Volume of PAT was measured from computed tomographic scans. Logistic regression was performed to examine the relationship between quartiles of PAT and diabetes. In regression models adjusted for field center, sex, race, age, systolic blood pressure, total cholesterol, log triglycerides, and treatment with blood pressure and cholesterol lowering medication, PAT volume in the 4th quartile was significantly associated with diabetes status after adjustment for BMI (OR 2.57, 95% CI 1.66, 3.98) or visceral adipose tissue (OR 2.08, 95% CI 1.32, 3.29). PAT volume in the 2nd and 3rd quartiles was not significantly associated with diabetes status relative to the first quartile. Conclusions: Metabolically active pericardial adipose tissue is associated with prevalent diabetes only at higher volumes independent of overall obesity.",

keywords = "Diabetes, Obesity, Pericardial adipose tissue, Visceral adipose tissue",

author = "Alman, {A. C.} and Jacobs, {D. R.} and Lewis, {C. E.} and Snell-Bergeon, {J. K.} and Carnethon, {M. R.} and Terry, {J. G.} and Goff, {D. C.} and J. Ding and Carr, {J. J.}",

note = "Funding Information: This project was funded by the National Heart, Lung, and Blood Institute in part though an investigator initiated grant to Vanderbilt University ( HL098445 ). The Coronary Artery Risk Development in Young Adults Study (CARDIA) is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham ( HHSN268201300025C & HHSN268201300026C ), Northwestern University ( HHSN268201300027C ), University of Minnesota ( HHSN268201300028C ), Kaiser Foundation Research Institute ( HHSN268201300029C ), and Johns Hopkins University School of Medicine ( HHSN268200900041C ). CARDIA is also partially supported by the Intramural Research Program of the National Institute on Aging (NIA) and an intra-agency agreement between NIA and NHLBI ( AG0005 ). This manuscript has been reviewed by CARDIA for scientific content. Publisher Copyright: {\textcopyright} 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University.",

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doi = "10.1016/j.numecd.2015.12.011",

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TY - JOUR

T1 - Higher pericardial adiposity is associated with prevalent diabetes

T2 - The Coronary Artery Risk Development in Young Adults study

AU - Alman, A. C.

AU - Jacobs, D. R.

AU - Lewis, C. E.

AU - Snell-Bergeon, J. K.

AU - Carnethon, M. R.

AU - Terry, J. G.

AU - Goff, D. C.

AU - Ding, J.

AU - Carr, J. J.

N1 - Funding Information: This project was funded by the National Heart, Lung, and Blood Institute in part though an investigator initiated grant to Vanderbilt University ( HL098445 ). The Coronary Artery Risk Development in Young Adults Study (CARDIA) is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham ( HHSN268201300025C & HHSN268201300026C ), Northwestern University ( HHSN268201300027C ), University of Minnesota ( HHSN268201300028C ), Kaiser Foundation Research Institute ( HHSN268201300029C ), and Johns Hopkins University School of Medicine ( HHSN268200900041C ). CARDIA is also partially supported by the Intramural Research Program of the National Institute on Aging (NIA) and an intra-agency agreement between NIA and NHLBI ( AG0005 ). This manuscript has been reviewed by CARDIA for scientific content. Publisher Copyright: © 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background and aims: Pericardial adipose tissue (PAT) is located on both sides of the pericardium. We tested whether PAT was associated with prevalent diabetes at the year 25 exam of the Coronary Artery Risk Development in Young Adults (CARDIA) study. Methods and results: The CARDIA Year 25 exam (2010-2011) included complete data for all covariates on 3107 participants. Prevalent diabetes (n = 436) was defined as high fasting (≥126 mg/dl) or 2-h postload glucose (≥200 mg/dl) or HbA1c (≥6.5%) or use of diabetes medications. Volume of PAT was measured from computed tomographic scans. Logistic regression was performed to examine the relationship between quartiles of PAT and diabetes. In regression models adjusted for field center, sex, race, age, systolic blood pressure, total cholesterol, log triglycerides, and treatment with blood pressure and cholesterol lowering medication, PAT volume in the 4th quartile was significantly associated with diabetes status after adjustment for BMI (OR 2.57, 95% CI 1.66, 3.98) or visceral adipose tissue (OR 2.08, 95% CI 1.32, 3.29). PAT volume in the 2nd and 3rd quartiles was not significantly associated with diabetes status relative to the first quartile. Conclusions: Metabolically active pericardial adipose tissue is associated with prevalent diabetes only at higher volumes independent of overall obesity.

AB - Background and aims: Pericardial adipose tissue (PAT) is located on both sides of the pericardium. We tested whether PAT was associated with prevalent diabetes at the year 25 exam of the Coronary Artery Risk Development in Young Adults (CARDIA) study. Methods and results: The CARDIA Year 25 exam (2010-2011) included complete data for all covariates on 3107 participants. Prevalent diabetes (n = 436) was defined as high fasting (≥126 mg/dl) or 2-h postload glucose (≥200 mg/dl) or HbA1c (≥6.5%) or use of diabetes medications. Volume of PAT was measured from computed tomographic scans. Logistic regression was performed to examine the relationship between quartiles of PAT and diabetes. In regression models adjusted for field center, sex, race, age, systolic blood pressure, total cholesterol, log triglycerides, and treatment with blood pressure and cholesterol lowering medication, PAT volume in the 4th quartile was significantly associated with diabetes status after adjustment for BMI (OR 2.57, 95% CI 1.66, 3.98) or visceral adipose tissue (OR 2.08, 95% CI 1.32, 3.29). PAT volume in the 2nd and 3rd quartiles was not significantly associated with diabetes status relative to the first quartile. Conclusions: Metabolically active pericardial adipose tissue is associated with prevalent diabetes only at higher volumes independent of overall obesity.

KW - Diabetes

KW - Obesity

KW - Pericardial adipose tissue

KW - Visceral adipose tissue

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AN - SCOPUS:84955239246

VL - 26

SP - 326

EP - 332

JO - Nutrition, Metabolism and Cardiovascular Diseases

JF - Nutrition, Metabolism and Cardiovascular Diseases

SN - 0939-4753

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ER -

Higher pericardial adiposity is associated with prevalent diabetes: The Coronary Artery Risk Development in Young Adults study

Abstract

Bibliographical note

Keywords

UN SDGs

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