TY - JOUR
T1 - High‐dose methotrexate for the remission induction of refractory adult acute lymphocytic leukemia
AU - Peterson, Bruce A
AU - Bloomfield, Clara D.
PY - 1978
Y1 - 1978
N2 - Six adults with refractory acute lymphocytic leukemia (ALL) were treated with high‐dose methotrexate, citrovorum factor, and vincristine. All patients had previously received extensive treatment with standard therapeutic agents, including vincristine, and all but one had received prior methotrexate. Two patients achieved complete remission and one achieved partial remission. Responses were seen at 3–6 gm/m2 of methotrexate. The durations of remission were 7–10 weeks. High‐dose methotrexate with citrovorum factor is effective in the treatment of advanced ALL and should be considered for inclusion in initial combination chemotherapeutic regimens for adult ALL.
AB - Six adults with refractory acute lymphocytic leukemia (ALL) were treated with high‐dose methotrexate, citrovorum factor, and vincristine. All patients had previously received extensive treatment with standard therapeutic agents, including vincristine, and all but one had received prior methotrexate. Two patients achieved complete remission and one achieved partial remission. Responses were seen at 3–6 gm/m2 of methotrexate. The durations of remission were 7–10 weeks. High‐dose methotrexate with citrovorum factor is effective in the treatment of advanced ALL and should be considered for inclusion in initial combination chemotherapeutic regimens for adult ALL.
KW - acute lymphocytic leukemia
KW - chemotherapy
KW - high‐dose methotrexate
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U2 - 10.1002/mpo.2950050112
DO - 10.1002/mpo.2950050112
M3 - Article
C2 - 370537
AN - SCOPUS:0018196695
SN - 0098-1532
VL - 5
SP - 79
EP - 84
JO - Medical and Pediatric Oncology
JF - Medical and Pediatric Oncology
IS - 1
ER -
