High-throughput screens to discover small-molecule modulators of ryanodine receptor calcium release channels

Keyphrases

• Accessory Protein 16%
• Ca2+ 33%
• Ca2+ Regulation 16%
• Calmodulin 33%
• Cardiomyopathy 16%
• Channel Opening 16%
• Diabetes 16%
• Dose-response 16%
• Dysregulation 16%
• FKBP12.6 16%
• Functional Readouts 16%
• High-throughput Screening 100%
• Intracellular Ca2+ 16%
• Intracellular Ca2+ Channel 16%
• Muscle Function 16%
• Neurological Disorders 16%
• Pathological State 16%
• Pharmacological Agents 16%
• Receptor Binding 16%
• Receptor Modulators 16%
• Ryanodine 16%
• Ryanodine Receptor 100%
• Ryanodine Receptor Calcium Release Channel 100%
• RYR1 50%
• Screening Method 33%
• Single-molecule Fluorescence Resonance Energy Transfer (smFRET) 83%
• Skeletal Myopathy 16%
• Small Molecule Modulators 100%
• Striated muscle 16%
• Therapeutic Use 16%
• Tight 16%
• Transfer Based 16%
• Z-factor 16%

Biochemistry, Genetics and Molecular Biology

• Calcium Channel 14%
• Calmodulin 28%
• Dose Response 14%
• Fluorescence Resonance Energy Transfer 71%
• Muscle Function 14%
• Receptor Binding 14%
• Ryanodine Receptor 100%
• Small Molecule 100%

Pharmacology, Toxicology and Pharmaceutical Science

• Calcium Channel 14%
• Calcium Ion 42%
• Calmodulin 28%
• Myopathy 14%
• Ryanodine 14%
• Ryanodine Receptor 100%