High-throughput parallel synthesis of 3,4-disubstituted 1-(ω-hydroxyalkyl) imidazolin-2-ones on 'volatilizable' supports

Yangmei Li; Yongping Yu; Marc Giulianotti; Richard A. Houghten

doi:10.1016/j.tetlet.2008.03.156

High-throughput parallel synthesis of 3,4-disubstituted 1-(ω-hydroxyalkyl) imidazolin-2-ones on 'volatilizable' supports

Yangmei Li, Yongping Yu, Marc Giulianotti, Richard A. Houghten

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A solid-phase synthesis of 3,4-disubstituted 1-(ω-hydroxyalkyl) imidazolin-2-ones on the 'volatilizable' aminoalkyl functionalized silica gel is reported. The desired products were cleaved by a two-step procedure in good purity and yield.

Original language	English (US)
Pages (from-to)	3632-3633
Number of pages	2
Journal	Tetrahedron Letters
Volume	49
Issue number	22
DOIs	https://doi.org/10.1016/j.tetlet.2008.03.156
State	Published - May 26 2008
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by the National Science Foundation (R.A.H. NSF4501), the National Science Foundation of China (Y.Y. NSFC20572098), and Zhejiang Science and Technology Programme (Y.Y. 2005c3401).

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10.1016/j.tetlet.2008.03.156

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title = "High-throughput parallel synthesis of 3,4-disubstituted 1-(ω-hydroxyalkyl) imidazolin-2-ones on 'volatilizable' supports",

abstract = "A solid-phase synthesis of 3,4-disubstituted 1-(ω-hydroxyalkyl) imidazolin-2-ones on the 'volatilizable' aminoalkyl functionalized silica gel is reported. The desired products were cleaved by a two-step procedure in good purity and yield.",

author = "Yangmei Li and Yongping Yu and Marc Giulianotti and Houghten, {Richard A.}",

note = "Funding Information: This work was supported by the National Science Foundation (R.A.H. NSF4501), the National Science Foundation of China (Y.Y. NSFC20572098), and Zhejiang Science and Technology Programme (Y.Y. 2005c3401).",

year = "2008",

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doi = "10.1016/j.tetlet.2008.03.156",

language = "English (US)",

volume = "49",

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journal = "Tetrahedron Letters",

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T1 - High-throughput parallel synthesis of 3,4-disubstituted 1-(ω-hydroxyalkyl) imidazolin-2-ones on 'volatilizable' supports

AU - Li, Yangmei

AU - Yu, Yongping

AU - Giulianotti, Marc

AU - Houghten, Richard A.

N1 - Funding Information: This work was supported by the National Science Foundation (R.A.H. NSF4501), the National Science Foundation of China (Y.Y. NSFC20572098), and Zhejiang Science and Technology Programme (Y.Y. 2005c3401).

PY - 2008/5/26

Y1 - 2008/5/26

N2 - A solid-phase synthesis of 3,4-disubstituted 1-(ω-hydroxyalkyl) imidazolin-2-ones on the 'volatilizable' aminoalkyl functionalized silica gel is reported. The desired products were cleaved by a two-step procedure in good purity and yield.

AB - A solid-phase synthesis of 3,4-disubstituted 1-(ω-hydroxyalkyl) imidazolin-2-ones on the 'volatilizable' aminoalkyl functionalized silica gel is reported. The desired products were cleaved by a two-step procedure in good purity and yield.

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U2 - 10.1016/j.tetlet.2008.03.156

DO - 10.1016/j.tetlet.2008.03.156

M3 - Article

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SN - 0040-4039

VL - 49

SP - 3632

EP - 3633

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 22

ER -

High-throughput parallel synthesis of 3,4-disubstituted 1-(ω-hydroxyalkyl) imidazolin-2-ones on 'volatilizable' supports

Abstract

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