High throughput migration assay of microenvironmental factors of metastasis

Marie Elena Brett; David K Wood

High throughput migration assay of microenvironmental factors of metastasis

Marie Elena Brett
, David K Wood

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We have developed a novel high throughput assay to analyze cell migration within complex 3D microenvironments. This platform will enable the discovery of the cues that promote metastatic tumor cell migration. Metastasis is universally recognized as the primary cause of cancer mortality, yet this stage of cancer progression remains the least understood and most difficult to study. There is need to systematically explore microenvironmental factors that influence cell migration, but current methods are throughput limited and do not recapitulate physiological conditions. To overcome these obstacles, we combine rapid 3D tissue generation with high throughput flow analysis to quantify cell migration.

Original language	English (US)
Title of host publication	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Publisher	Chemical and Biological Microsystems Society
Pages	639-641
Number of pages	3
ISBN (Electronic)	9780979806476
State	Published - 2014
Event	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States Duration: Oct 26 2014 → Oct 30 2014

Publication series

Name	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Other

Other	18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Country/Territory	United States
City	San Antonio
Period	10/26/14 → 10/30/14

Bibliographical note

Publisher Copyright:
© 14CBMS.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cell migration
Droplets
Metastasis

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Brett, M. E., & Wood, D. K. (2014). High throughput migration assay of microenvironmental factors of metastasis. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 639-641). (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014). Chemical and Biological Microsystems Society.

High throughput migration assay of microenvironmental factors of metastasis. / Brett, Marie Elena; Wood, David K.
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. p. 639-641 (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Brett, ME & Wood, DK 2014, High throughput migration assay of microenvironmental factors of metastasis. in 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, Chemical and Biological Microsystems Society, pp. 639-641, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, San Antonio, United States, 10/26/14.

Brett, Marie Elena ; Wood, David K. / High throughput migration assay of microenvironmental factors of metastasis. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, 2014. pp. 639-641 (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014).

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title = "High throughput migration assay of microenvironmental factors of metastasis",

abstract = "We have developed a novel high throughput assay to analyze cell migration within complex 3D microenvironments. This platform will enable the discovery of the cues that promote metastatic tumor cell migration. Metastasis is universally recognized as the primary cause of cancer mortality, yet this stage of cancer progression remains the least understood and most difficult to study. There is need to systematically explore microenvironmental factors that influence cell migration, but current methods are throughput limited and do not recapitulate physiological conditions. To overcome these obstacles, we combine rapid 3D tissue generation with high throughput flow analysis to quantify cell migration.",

keywords = "Cell migration, Droplets, Metastasis",

author = "Brett, \{Marie Elena\} and Wood, \{David K\}",

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year = "2014",

language = "English (US)",

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AU - Wood, David K

PY - 2014

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N2 - We have developed a novel high throughput assay to analyze cell migration within complex 3D microenvironments. This platform will enable the discovery of the cues that promote metastatic tumor cell migration. Metastasis is universally recognized as the primary cause of cancer mortality, yet this stage of cancer progression remains the least understood and most difficult to study. There is need to systematically explore microenvironmental factors that influence cell migration, but current methods are throughput limited and do not recapitulate physiological conditions. To overcome these obstacles, we combine rapid 3D tissue generation with high throughput flow analysis to quantify cell migration.

AB - We have developed a novel high throughput assay to analyze cell migration within complex 3D microenvironments. This platform will enable the discovery of the cues that promote metastatic tumor cell migration. Metastasis is universally recognized as the primary cause of cancer mortality, yet this stage of cancer progression remains the least understood and most difficult to study. There is need to systematically explore microenvironmental factors that influence cell migration, but current methods are throughput limited and do not recapitulate physiological conditions. To overcome these obstacles, we combine rapid 3D tissue generation with high throughput flow analysis to quantify cell migration.

KW - Cell migration

KW - Droplets

KW - Metastasis

UR - https://www.scopus.com/pages/publications/84941642121

UR - https://www.scopus.com/pages/publications/84941642121#tab=citedBy

M3 - Conference contribution

AN - SCOPUS:84941642121

T3 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

SP - 639

EP - 641

BT - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

PB - Chemical and Biological Microsystems Society

T2 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Y2 - 26 October 2014 through 30 October 2014

ER -

High throughput migration assay of microenvironmental factors of metastasis

Abstract

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Bibliographical note

UN SDGs

Keywords

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