High throughput migration assay of microenvironmental factors of metastasis

Marie Elena Brett, David K Wood

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have developed a novel high throughput assay to analyze cell migration within complex 3D microenvironments. This platform will enable the discovery of the cues that promote metastatic tumor cell migration. Metastasis is universally recognized as the primary cause of cancer mortality, yet this stage of cancer progression remains the least understood and most difficult to study. There is need to systematically explore microenvironmental factors that influence cell migration, but current methods are throughput limited and do not recapitulate physiological conditions. To overcome these obstacles, we combine rapid 3D tissue generation with high throughput flow analysis to quantify cell migration.

Original languageEnglish (US)
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages639-641
Number of pages3
ISBN (Electronic)9780979806476
StatePublished - Jan 1 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: Oct 26 2014Oct 30 2014

Other

Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUnited States
CitySan Antonio
Period10/26/1410/30/14

Keywords

  • Cell migration
  • Droplets
  • Metastasis

Fingerprint Dive into the research topics of 'High throughput migration assay of microenvironmental factors of metastasis'. Together they form a unique fingerprint.

Cite this