High-throughput microfluidic chip for automated in vitro release testing

M. Alberti, Y. Dancik, B. Wu, Z. Feng, R. G. Wu, M. Bigliardi-Qi, P. L. Bigliardi, Z. P. Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A multiple chamber microfluidic system for in vitro release and skin permeability testing has been developed. Infinite dose permeation studies with salicylic acid (SA) applied on silicone membranes were run in the microfluidic chip and in six Franz diffusion cells. The diffusion profiles are comparable in the two systems, however the steady state flux measured in the chip is 35% higher. Due to the small volumes and the continuous flow in the microfluidic chambers, the chip enables more accurate permeation profiles with coefficients of variations (CV) below 5% at steady state.

Original languageEnglish (US)
Title of host publication20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PublisherChemical and Biological Microsystems Society
Pages589-590
Number of pages2
ISBN (Electronic)9780979806490
StatePublished - Jan 1 2016
Event20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland
Duration: Oct 9 2016Oct 13 2016

Other

Other20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
CountryIreland
CityDublin
Period10/9/1610/13/16

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Keywords

  • High-throughput
  • In vitro release
  • Skin permeability
  • Skin-on-a-chip

Cite this

Alberti, M., Dancik, Y., Wu, B., Feng, Z., Wu, R. G., Bigliardi-Qi, M., Bigliardi, P. L., & Wang, Z. P. (2016). High-throughput microfluidic chip for automated in vitro release testing. In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 (pp. 589-590). Chemical and Biological Microsystems Society.