High Sensitivity Thermochemical Analysis

Earl B. Smith, Charles S. Barnes, Peter W. Carr

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


A lock-in amplifier and linear ramp generator system has been developed which permits an rms temperature resolution of 3-4 m°C. This temperature resolution approximates the theoretical Johnson noise limit of the signal source. The system was employed to improve the sensitivity of thermometric analysis. In a 100-ml calorimetrie vessel, solutions of 15 nM perchloric acid have been titrated with sodium hydroxide with a precision and accuracy of better than 10%. This reaction generated 20 millicalories of heat and caused a temperature change of approximately 0.2 m°C. At higher concentrations (1.5mM) the optimum precision achieved was 0.2%, which is the limiting precision of the volume delivery device.

Original languageEnglish (US)
Pages (from-to)1663-1669
Number of pages7
JournalAnalytical chemistry
Issue number9
StatePublished - Aug 1 1972


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