High-resolution whole-brain diffusion MRI at 7T using radiofrequency parallel transmission

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4 Citations (Scopus)

Abstract

Purpose: Investigating the utility of RF parallel transmission (pTx) for Human Connectome Project (HCP)-style whole-brain diffusion MRI (dMRI) data at 7 Tesla (7T). Methods: Healthy subjects were scanned in pTx and single-transmit (1Tx) modes. Multiband (MB), single-spoke pTx pulses were designed to image sagittal slices. HCP-style dMRI data (i.e., 1.05-mm resolutions, MB2, b-values = 1000/2000 s/mm 2 , 286 images and 40-min scan) and data with higher accelerations (MB3 and MB4) were acquired with pTx. Results: pTx significantly improved flip-angle detected signal uniformity across the brain, yielding ∼19% increase in temporal SNR (tSNR) averaged over the brain relative to 1Tx. This allowed significantly enhanced estimation of multiple fiber orientations (with ∼21% decrease in dispersion) in HCP-style 7T dMRI datasets. Additionally, pTx pulses achieved substantially lower power deposition, permitting higher accelerations, enabling collection of the same data in 2/3 and 1/2 the scan time or of more data in the same scan time. Conclusion: pTx provides a solution to two major limitations for slice-accelerated high-resolution whole-brain dMRI at 7T; it improves flip-angle uniformity, and enables higher slice acceleration relative to current state-of-the-art. As such, pTx provides significant advantages for rapid acquisition of high-quality, high-resolution truly whole-brain dMRI data.

Original languageEnglish (US)
Pages (from-to)1857-1870
Number of pages14
JournalMagnetic resonance in medicine
Volume80
Issue number5
DOIs
StatePublished - Nov 1 2018

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Diffusion Magnetic Resonance Imaging
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Keywords

  • Human Connectome Project
  • diffusion MRI
  • high-field MRI
  • parallel transmission
  • simultaneous multi-slice

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural

Cite this

@article{c4aef03327064a6d83ed75ebee9d84b2,
title = "High-resolution whole-brain diffusion MRI at 7T using radiofrequency parallel transmission",
abstract = "Purpose: Investigating the utility of RF parallel transmission (pTx) for Human Connectome Project (HCP)-style whole-brain diffusion MRI (dMRI) data at 7 Tesla (7T). Methods: Healthy subjects were scanned in pTx and single-transmit (1Tx) modes. Multiband (MB), single-spoke pTx pulses were designed to image sagittal slices. HCP-style dMRI data (i.e., 1.05-mm resolutions, MB2, b-values = 1000/2000 s/mm 2 , 286 images and 40-min scan) and data with higher accelerations (MB3 and MB4) were acquired with pTx. Results: pTx significantly improved flip-angle detected signal uniformity across the brain, yielding ∼19{\%} increase in temporal SNR (tSNR) averaged over the brain relative to 1Tx. This allowed significantly enhanced estimation of multiple fiber orientations (with ∼21{\%} decrease in dispersion) in HCP-style 7T dMRI datasets. Additionally, pTx pulses achieved substantially lower power deposition, permitting higher accelerations, enabling collection of the same data in 2/3 and 1/2 the scan time or of more data in the same scan time. Conclusion: pTx provides a solution to two major limitations for slice-accelerated high-resolution whole-brain dMRI at 7T; it improves flip-angle uniformity, and enables higher slice acceleration relative to current state-of-the-art. As such, pTx provides significant advantages for rapid acquisition of high-quality, high-resolution truly whole-brain dMRI data.",
keywords = "Human Connectome Project, diffusion MRI, high-field MRI, parallel transmission, simultaneous multi-slice",
author = "Xiaoping Wu and Auerbach, {Edward J} and Vu, {An T.} and Steen Moeller and Christophe Lenglet and Sebastian Schmitter and {Van de Moortele}, Pierre-Francois and Essa Yacoub and Kamil Ugurbil",
year = "2018",
month = "11",
day = "1",
doi = "10.1002/mrm.27189",
language = "English (US)",
volume = "80",
pages = "1857--1870",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
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TY - JOUR

T1 - High-resolution whole-brain diffusion MRI at 7T using radiofrequency parallel transmission

AU - Wu, Xiaoping

AU - Auerbach, Edward J

AU - Vu, An T.

AU - Moeller, Steen

AU - Lenglet, Christophe

AU - Schmitter, Sebastian

AU - Van de Moortele, Pierre-Francois

AU - Yacoub, Essa

AU - Ugurbil, Kamil

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Purpose: Investigating the utility of RF parallel transmission (pTx) for Human Connectome Project (HCP)-style whole-brain diffusion MRI (dMRI) data at 7 Tesla (7T). Methods: Healthy subjects were scanned in pTx and single-transmit (1Tx) modes. Multiband (MB), single-spoke pTx pulses were designed to image sagittal slices. HCP-style dMRI data (i.e., 1.05-mm resolutions, MB2, b-values = 1000/2000 s/mm 2 , 286 images and 40-min scan) and data with higher accelerations (MB3 and MB4) were acquired with pTx. Results: pTx significantly improved flip-angle detected signal uniformity across the brain, yielding ∼19% increase in temporal SNR (tSNR) averaged over the brain relative to 1Tx. This allowed significantly enhanced estimation of multiple fiber orientations (with ∼21% decrease in dispersion) in HCP-style 7T dMRI datasets. Additionally, pTx pulses achieved substantially lower power deposition, permitting higher accelerations, enabling collection of the same data in 2/3 and 1/2 the scan time or of more data in the same scan time. Conclusion: pTx provides a solution to two major limitations for slice-accelerated high-resolution whole-brain dMRI at 7T; it improves flip-angle uniformity, and enables higher slice acceleration relative to current state-of-the-art. As such, pTx provides significant advantages for rapid acquisition of high-quality, high-resolution truly whole-brain dMRI data.

AB - Purpose: Investigating the utility of RF parallel transmission (pTx) for Human Connectome Project (HCP)-style whole-brain diffusion MRI (dMRI) data at 7 Tesla (7T). Methods: Healthy subjects were scanned in pTx and single-transmit (1Tx) modes. Multiband (MB), single-spoke pTx pulses were designed to image sagittal slices. HCP-style dMRI data (i.e., 1.05-mm resolutions, MB2, b-values = 1000/2000 s/mm 2 , 286 images and 40-min scan) and data with higher accelerations (MB3 and MB4) were acquired with pTx. Results: pTx significantly improved flip-angle detected signal uniformity across the brain, yielding ∼19% increase in temporal SNR (tSNR) averaged over the brain relative to 1Tx. This allowed significantly enhanced estimation of multiple fiber orientations (with ∼21% decrease in dispersion) in HCP-style 7T dMRI datasets. Additionally, pTx pulses achieved substantially lower power deposition, permitting higher accelerations, enabling collection of the same data in 2/3 and 1/2 the scan time or of more data in the same scan time. Conclusion: pTx provides a solution to two major limitations for slice-accelerated high-resolution whole-brain dMRI at 7T; it improves flip-angle uniformity, and enables higher slice acceleration relative to current state-of-the-art. As such, pTx provides significant advantages for rapid acquisition of high-quality, high-resolution truly whole-brain dMRI data.

KW - Human Connectome Project

KW - diffusion MRI

KW - high-field MRI

KW - parallel transmission

KW - simultaneous multi-slice

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U2 - 10.1002/mrm.27189

DO - 10.1002/mrm.27189

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VL - 80

SP - 1857

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JF - Magnetic Resonance in Medicine

SN - 0740-3194

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