High resolution whole brain diffusion imaging at 7T for the Human Connectome Project

A. T. Vu, E. Auerbach, C. Lenglet, S. Moeller, S. N. Sotiropoulos, S. Jbabdi, J. Andersson, E. Yacoub, K. Ugurbil

Research output: Contribution to journalArticlepeer-review

107 Scopus citations


Mapping structural connectivity in healthy adults for the Human Connectome Project (HCP) benefits from high quality, high resolution, multiband (MB)-accelerated whole brain diffusion MRI (dMRI). Acquiring such data at ultrahigh fields (7T and above) can improve intrinsic signal-to-noise ratio (SNR), but suffers from shorter T2 and T2* relaxation times, increased B1+ inhomogeneity (resulting in signal loss in cerebellar and temporal lobe regions), and increased power deposition (i.e. specific absorption rate (SAR)), thereby limiting our ability to reduce the repetition time (TR). Here, we present recent developments and optimizations in 7T image acquisitions for the HCP that allow us to efficiently obtain high quality, high resolution whole brain in-vivo dMRI data at 7T. These data show spatial details typically seen only in ex-vivo studies and complement already very high quality 3T HCP data in the same subjects. The advances are the result of intensive pilot studies aimed at mitigating the limitations of dMRI at 7T. The data quality and methods described here are representative of the datasets that will be made freely available to the community in 2015.

Original languageEnglish (US)
Pages (from-to)318-331
Number of pages14
StatePublished - Nov 15 2015

Bibliographical note

Funding Information:
The work reported in this article was supported by the Human Connectome Project ( 1U54MH091657 ) from the 16 Institutes and Centers of the National Institutes of Health that support the NIH Blueprint for Neuroscience Research and by the Biotechnology Research Center (BTRC) grant P41 EB015894 from NIBIB and the NINDS Institutional Center Core Grant P30 NS076408 .

Publisher Copyright:
© 2015 Elsevier Inc.


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