TY - JOUR
T1 - High-resolution mapping of myeloarchitecture in vivo
T2 - Localization of auditory areas in the human brain
AU - De Martino, Federico
AU - Moerel, Michelle
AU - Xu, Junqian
AU - Van De Moortele, Pierre Francois
AU - Ugurbil, Kamil
AU - Goebel, Rainer
AU - Yacoub, Essa
AU - Formisano, Elia
N1 - Publisher Copyright:
© 2014 The Author.
PY - 2015/10
Y1 - 2015/10
N2 - The precise delineation of auditory areas in vivo remains problematic. Histological analysis of postmortem tissue indicates that the relation of areal borders to macroanatomical landmarks is variable across subjects. Furthermore, functional parcellation schemes based on measures of, for example, frequency preference (tonotopy) remain controversial. Here, we propose a 7 Tesla magnetic resonance imaging method that enables the anatomical delineation of auditory cortical areas in vivo and in individual brains, through the high-resolution visualization (0.6×0.6×0.6 mm3) of intracortical anatomical contrast related to myelin. The approach combines the acquisition and analysis of images with multiple MR contrasts (T1, T2∗, and proton density). Compared with previous methods, the proposed solution is feasible at high fields and time efficient, which allows collecting myelin-related and functional images within the same measurement session. Our results show that a data-driven analysis of cortical depth-dependent profiles of anatomical contrast allows identifying a most densely myelinated cortical region on the medial Heschl's gyrus. Analyses of functional responses show that this region includes neuronal populations with typical primary functional properties (single tonotopic gradient and narrow frequency tuning), thus indicating that it may correspond to the human homolog of monkey A1.
AB - The precise delineation of auditory areas in vivo remains problematic. Histological analysis of postmortem tissue indicates that the relation of areal borders to macroanatomical landmarks is variable across subjects. Furthermore, functional parcellation schemes based on measures of, for example, frequency preference (tonotopy) remain controversial. Here, we propose a 7 Tesla magnetic resonance imaging method that enables the anatomical delineation of auditory cortical areas in vivo and in individual brains, through the high-resolution visualization (0.6×0.6×0.6 mm3) of intracortical anatomical contrast related to myelin. The approach combines the acquisition and analysis of images with multiple MR contrasts (T1, T2∗, and proton density). Compared with previous methods, the proposed solution is feasible at high fields and time efficient, which allows collecting myelin-related and functional images within the same measurement session. Our results show that a data-driven analysis of cortical depth-dependent profiles of anatomical contrast allows identifying a most densely myelinated cortical region on the medial Heschl's gyrus. Analyses of functional responses show that this region includes neuronal populations with typical primary functional properties (single tonotopic gradient and narrow frequency tuning), thus indicating that it may correspond to the human homolog of monkey A1.
KW - Auditory cortex
KW - Cortical myelin-related contrast
KW - High-field MRI
KW - Tonotopy
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U2 - 10.1093/cercor/bhu150
DO - 10.1093/cercor/bhu150
M3 - Article
C2 - 24994817
AN - SCOPUS:84945909034
SN - 1047-3211
VL - 25
SP - 3394
EP - 3405
JO - Cerebral Cortex
JF - Cerebral Cortex
IS - 10
ER -