High-resolution fMRI mapping of ocular dominance layers in cat lateral geniculate nucleus

Nanyin Zhang, Xiao Hong Zhu, Yi Zhang, Jae keun Park, Wei Chen

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Abstract

In this work, we exploited the superior capability of high-resolution functional magnetic resonance imaging (fMRI) for functional mapping of ocular dominance layer (ODL) in the cat lateral geniculate nucleus (LGN). The stimulus-evoked neuronal activities in the LGN ODLs associated with contralateral- and ipsilateral-eye visual inputs were successfully differentiated and mapped using both blood-oxygenation-level dependent (BOLD)-weighted and cerebral blood volume (CBV)-weighted fMRI methods. The morphology of mapped LGN ODLs was in remarkable consistency with histology findings in terms of ODL shape, orientation, thickness and eye-dominance. Compared with the BOLD signal, the CBV signal provides higher reproducibility and better spatial resolvability for function mapping of LGN because of improved contrast-to-noise ratio and point-spread function. The capability of fMRI for non-invasively imaging the functional sub-units of ODL in a small LGN overcomes the limitation of conventional neural-recording approach, and it opens a new opportunity for studying critical roles of LGN in brain function and dysfunction at the fine scale of ocular dominance layer.

Original languageEnglish (US)
Pages (from-to)1456-1463
Number of pages8
JournalNeuroImage
Volume50
Issue number4
DOIs
StatePublished - May 1 2010

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Keywords

  • Blood-oxygenation-level-dependent (BOLD)
  • Cerebral blood volume (CBV)
  • Functional MRI (fMRI)
  • Lateral geniculate nucleus (LGN)
  • Ocular dominance layer (ODL)

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