High renin in heart failure: A manifestation of hyponatremia

T. B. Levine, Jay N Cohn, T. Vrobel, J. A. Franciosa

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Activation of the renin-angiotensin system in patients with congestive heart failure (CHF) has been proposed as one mechanism for maintaining blood pressure in the face of a reduced cardiac output. Plasma renin activity (PRA) has been shown to vary widely in CHF from low to very high levels. It is not known what causes increased renin release in some patients and not in others. Altered renal perfusion or function in CHF have been thought to be factors in renin release. Recently, the severity of CHF, as measured by pulmonary wedge pressure (PWP) was noted to correlate with PRA. The present study was undertaken to assess the influence of hemodynamics, renal function and electrolyte balance on PRA in patients with moderate to severe CHF.

Original languageEnglish (US)
Pages (from-to)203-207
Number of pages5
JournalTransactions of the Association of American Physicians
VolumeVol 92
StatePublished - Jan 1 1979


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