High prevalence of pulmonary findings in computed tomographies of HTLV-1-infected patients with and without adult-T cell leukemia/lymphoma–implications for staging

Ana Acuna-Villaorduna, Jesus Gonzalez-Lugo, B. Hilda Ye, Diego Andres Adrianzen Herrera, R. Alejandro Sica, Urvi Shah, Nishi Shah, Noah Kornblum, Ira Braunschweig, Olga Derman, Ioannis Mantzaris, Aditi Shastri, Yanhua Wang, Amit Verma, Benjamin Zalta, Murali Janakiram

Research output: Contribution to journalArticle

Abstract

Lung involvement has been reported in HTLV-1 carriers and in patients with ATLL. Whether there are differences in the pattern of lung involvement between ATLL and HTLV carriers in North American patients is unknown. We aimed to compare CT pulmonary findings among patients with HTLV-1 infection with and without ATLL. Among 140 patients with HTLV-1 diagnosis, 97 had CT chest available. Of these, 72 (74.2%) had ATLL and 25 (25.8%) did not have ATLL. CT chest abnormalities were present in 90 (92.8%) participants (94.4% in ATLL; 88% in non-ATLL). Higher rates of lymphadenopathy (69.4% versus 24%, p <.01) and lower rates of bronchiectasis (25% versus 48%, p =.04) were seen in ATLL compared to non-ATLL. Our study supports that staging of lung involvement in ATLL should consider HTLV-associated pulmonary findings as not all CT chest abnormalities necessarily represent malignant infiltration.

Original languageEnglish (US)
Pages (from-to)3272-3276
Number of pages5
JournalLeukemia and Lymphoma
Volume60
Issue number13
DOIs
StatePublished - Nov 10 2019
Externally publishedYes

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Adult T Cell Leukemia Lymphoma
Human T-lymphotropic virus 1
Tomography
Lung
Thorax
Deltaretrovirus Infections
Bronchiectasis

Keywords

  • ATLL
  • HTLV-1
  • T-cell lymphoma

PubMed: MeSH publication types

  • Journal Article

Cite this

High prevalence of pulmonary findings in computed tomographies of HTLV-1-infected patients with and without adult-T cell leukemia/lymphoma–implications for staging. / Acuna-Villaorduna, Ana; Gonzalez-Lugo, Jesus; Ye, B. Hilda; Adrianzen Herrera, Diego Andres; Sica, R. Alejandro; Shah, Urvi; Shah, Nishi; Kornblum, Noah; Braunschweig, Ira; Derman, Olga; Mantzaris, Ioannis; Shastri, Aditi; Wang, Yanhua; Verma, Amit; Zalta, Benjamin; Janakiram, Murali.

In: Leukemia and Lymphoma, Vol. 60, No. 13, 10.11.2019, p. 3272-3276.

Research output: Contribution to journalArticle

Acuna-Villaorduna, A, Gonzalez-Lugo, J, Ye, BH, Adrianzen Herrera, DA, Sica, RA, Shah, U, Shah, N, Kornblum, N, Braunschweig, I, Derman, O, Mantzaris, I, Shastri, A, Wang, Y, Verma, A, Zalta, B & Janakiram, M 2019, 'High prevalence of pulmonary findings in computed tomographies of HTLV-1-infected patients with and without adult-T cell leukemia/lymphoma–implications for staging', Leukemia and Lymphoma, vol. 60, no. 13, pp. 3272-3276. https://doi.org/10.1080/10428194.2019.1627543
Acuna-Villaorduna, Ana ; Gonzalez-Lugo, Jesus ; Ye, B. Hilda ; Adrianzen Herrera, Diego Andres ; Sica, R. Alejandro ; Shah, Urvi ; Shah, Nishi ; Kornblum, Noah ; Braunschweig, Ira ; Derman, Olga ; Mantzaris, Ioannis ; Shastri, Aditi ; Wang, Yanhua ; Verma, Amit ; Zalta, Benjamin ; Janakiram, Murali. / High prevalence of pulmonary findings in computed tomographies of HTLV-1-infected patients with and without adult-T cell leukemia/lymphoma–implications for staging. In: Leukemia and Lymphoma. 2019 ; Vol. 60, No. 13. pp. 3272-3276.
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