High-performance anion exchange of small anions with polyethyleneimine-coated porous zirconia

Clayton McNeff, Qianhua Zhao, Peter W. Carr

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


The preparation and Chromatographic characterization of an ion-exchange high-performance liquid Chromatographic support by deposition and crosslinking of polyethyleneimine (PEI) on the surface of porous zirconia is described. Adsorption and evaporation methods were used for coating PEI onto the zirconia particles. These two stationary phases were compared by elemental analysis, ion-exchange capacity and by chromatography. High efficiency and good selectivity were observed for inorganic and organic anions. The addition of a strong, hard Lewis base to the mobile phase dramatically improved the peak shape and efficiency of para benzoic acid derivatives. PEI-coated zirconia showed a distinct elution sequence for organic anions when compared to bare zirconia or silica-based phases. The polyamine coated zirconia was stable over a pH range from 2.75 to 9. Flow studies, using nitrite as a probe solute, showed that both coating procedures produced packed columns with good mass-transfer properties.

Original languageEnglish (US)
Pages (from-to)201-211
Number of pages11
JournalJournal of Chromatography A
Issue number2
StatePublished - Nov 4 1994

Bibliographical note

Funding Information:
We would like to thank SarTec Corporation (Anoka, MN, USA.), the National Science Foundation (NSF), and the National Institutes of Health (NIH) for their support of this work.


Dive into the research topics of 'High-performance anion exchange of small anions with polyethyleneimine-coated porous zirconia'. Together they form a unique fingerprint.

Cite this