High-molecular-weight adiponectin and the risk of type 2 diabetes in the ARIC study

Na Zhu, Jim Pankow, Christie M. Ballantyne, David Couper, Ron C. Hoogeveen, Mark A Pereira, Bruce B. Duncan, Maria Inês Schmidt

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Context: Adiponectin, synthesized by adipocytes, has been shown to be a predictor of type 2 diabetes. Adiponectin circulates in plasma as three oligomeric isoforms. High-molecular-weight (HMW) adiponectin is thought to be the most biologically active form of adiponectin in terms of glucose homeostasis. Objective: Our objective was to investigate whether HMW adiponectin is more strongly associated with incident diabetes than is total adiponectin. Design: A nested case-cohort study was conducted in a population-based cohort of 9740 middle-aged, initially healthy, white and African-American participants of the Atherosclerosis Risk in Communities (ARIC) study followed for up to 9 yr. Plasma total and HMW adiponectin were measured by ELISA in 550 incident diabetes cases and 540 noncases. Results: Overall hazard ratios (95% confidence intervals) for developing diabetes for those in the fourth (vs. the first) quartile of total adiponectin, HMW adiponectin, and the ratio of HMW to total were 0.40 (0.25-0.64), 0.38 (0.23-0.63), and 0.65 (0.42-0.99), respectively, after adjustment for age, sex, ethnicity, study center, parental history of diabetes, hypertension, body mass index, and waist-to-hip ratio and 0.52 (0.32-0.85), 0.51 (0.31-0.86), and 0.77 (0.50-1.20), respectively, after additional adjustment for inflammation score (a score composed of six inflammation markers) and fasting insulin. When further adjusting for baseline fasting glucose, the graded associations were attenuated substantially and lost their gradation. Conclusions: In this community-based sample of U.S. adults, higher total and HMW adiponectin concentrations were similarly associated with a lower incidence of diabetes over 9 yr of follow-up.

Original languageEnglish (US)
Pages (from-to)5097-5104
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume95
Issue number11
DOIs
StatePublished - Jan 1 2010

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Adiponectin
Medical problems
Type 2 Diabetes Mellitus
Atherosclerosis
Molecular Weight
Molecular weight
Fasting
Inflammation
Plasmas
Glucose
Waist-Hip Ratio
Adipocytes
African Americans
Hazards
Protein Isoforms
Body Mass Index
Homeostasis
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Confidence Intervals

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High-molecular-weight adiponectin and the risk of type 2 diabetes in the ARIC study. / Zhu, Na; Pankow, Jim; Ballantyne, Christie M.; Couper, David; Hoogeveen, Ron C.; Pereira, Mark A; Duncan, Bruce B.; Schmidt, Maria Inês.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 95, No. 11, 01.01.2010, p. 5097-5104.

Research output: Contribution to journalArticle

Zhu, Na ; Pankow, Jim ; Ballantyne, Christie M. ; Couper, David ; Hoogeveen, Ron C. ; Pereira, Mark A ; Duncan, Bruce B. ; Schmidt, Maria Inês. / High-molecular-weight adiponectin and the risk of type 2 diabetes in the ARIC study. In: Journal of Clinical Endocrinology and Metabolism. 2010 ; Vol. 95, No. 11. pp. 5097-5104.
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T1 - High-molecular-weight adiponectin and the risk of type 2 diabetes in the ARIC study

AU - Zhu, Na

AU - Pankow, Jim

AU - Ballantyne, Christie M.

AU - Couper, David

AU - Hoogeveen, Ron C.

AU - Pereira, Mark A

AU - Duncan, Bruce B.

AU - Schmidt, Maria Inês

PY - 2010/1/1

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N2 - Context: Adiponectin, synthesized by adipocytes, has been shown to be a predictor of type 2 diabetes. Adiponectin circulates in plasma as three oligomeric isoforms. High-molecular-weight (HMW) adiponectin is thought to be the most biologically active form of adiponectin in terms of glucose homeostasis. Objective: Our objective was to investigate whether HMW adiponectin is more strongly associated with incident diabetes than is total adiponectin. Design: A nested case-cohort study was conducted in a population-based cohort of 9740 middle-aged, initially healthy, white and African-American participants of the Atherosclerosis Risk in Communities (ARIC) study followed for up to 9 yr. Plasma total and HMW adiponectin were measured by ELISA in 550 incident diabetes cases and 540 noncases. Results: Overall hazard ratios (95% confidence intervals) for developing diabetes for those in the fourth (vs. the first) quartile of total adiponectin, HMW adiponectin, and the ratio of HMW to total were 0.40 (0.25-0.64), 0.38 (0.23-0.63), and 0.65 (0.42-0.99), respectively, after adjustment for age, sex, ethnicity, study center, parental history of diabetes, hypertension, body mass index, and waist-to-hip ratio and 0.52 (0.32-0.85), 0.51 (0.31-0.86), and 0.77 (0.50-1.20), respectively, after additional adjustment for inflammation score (a score composed of six inflammation markers) and fasting insulin. When further adjusting for baseline fasting glucose, the graded associations were attenuated substantially and lost their gradation. Conclusions: In this community-based sample of U.S. adults, higher total and HMW adiponectin concentrations were similarly associated with a lower incidence of diabetes over 9 yr of follow-up.

AB - Context: Adiponectin, synthesized by adipocytes, has been shown to be a predictor of type 2 diabetes. Adiponectin circulates in plasma as three oligomeric isoforms. High-molecular-weight (HMW) adiponectin is thought to be the most biologically active form of adiponectin in terms of glucose homeostasis. Objective: Our objective was to investigate whether HMW adiponectin is more strongly associated with incident diabetes than is total adiponectin. Design: A nested case-cohort study was conducted in a population-based cohort of 9740 middle-aged, initially healthy, white and African-American participants of the Atherosclerosis Risk in Communities (ARIC) study followed for up to 9 yr. Plasma total and HMW adiponectin were measured by ELISA in 550 incident diabetes cases and 540 noncases. Results: Overall hazard ratios (95% confidence intervals) for developing diabetes for those in the fourth (vs. the first) quartile of total adiponectin, HMW adiponectin, and the ratio of HMW to total were 0.40 (0.25-0.64), 0.38 (0.23-0.63), and 0.65 (0.42-0.99), respectively, after adjustment for age, sex, ethnicity, study center, parental history of diabetes, hypertension, body mass index, and waist-to-hip ratio and 0.52 (0.32-0.85), 0.51 (0.31-0.86), and 0.77 (0.50-1.20), respectively, after additional adjustment for inflammation score (a score composed of six inflammation markers) and fasting insulin. When further adjusting for baseline fasting glucose, the graded associations were attenuated substantially and lost their gradation. Conclusions: In this community-based sample of U.S. adults, higher total and HMW adiponectin concentrations were similarly associated with a lower incidence of diabetes over 9 yr of follow-up.

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