Abstract
The choice of a polymeric support is a key factor for the success of solid-phase methods for syntheses of organic compounds and biomolecules such as peptides and oligonucleotides. Classical Merrifield solid-phase peptide synthesis (SPPS), performed on low cross-linked hydro-phobic polystyrene (PS) beads, sometimes suffers from sequence-dependent coupling difficulties. The concept of incorporating polyethylene glycol (PEG) into supports for solid- phase synthesis represents a successful approach to alleviating such problems. Previous reports from our laboratories have shown the advantages of 'low-load' PEG-PS(0.15-0.25 mmol/g) for SPPS. Herein, we demonstrate that the beneficial aspects of the PEG-PS concept can be extended with resins that have higher loadings (0.3-0.5 mmol/g).
Original language | English (US) |
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Pages (from-to) | 365-380 |
Number of pages | 16 |
Journal | Biopolymers - Peptide Science Section |
Volume | 47 |
Issue number | 5 |
DOIs | |
State | Published - 1998 |
Keywords
- Chemical libraries
- Polyethylene glycol-polystyrene (PEG- PS)
- Polymeric supports
- Solid-phase combinatorial chemistry
- Solid-phase peptide synthesis