'High-Load' Polyethylene glycol-Polystyrene (PEG-PS) graft supports for solid-phase synthesis

Steven A. Kates, Brian F. McGuinness, Christopher Blackburn, G. William Griffin, Nuriá A. Solé, George Barany, Fernando Albericio

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

The choice of a polymeric support is a key factor for the success of solid-phase methods for syntheses of organic compounds and biomolecules such as peptides and oligonucleotides. Classical Merrifield solid-phase peptide synthesis (SPPS), performed on low cross-linked hydro-phobic polystyrene (PS) beads, sometimes suffers from sequence-dependent coupling difficulties. The concept of incorporating polyethylene glycol (PEG) into supports for solid- phase synthesis represents a successful approach to alleviating such problems. Previous reports from our laboratories have shown the advantages of 'low-load' PEG-PS(0.15-0.25 mmol/g) for SPPS. Herein, we demonstrate that the beneficial aspects of the PEG-PS concept can be extended with resins that have higher loadings (0.3-0.5 mmol/g).

Original languageEnglish (US)
Pages (from-to)365-380
Number of pages16
JournalBiopolymers - Peptide Science Section
Volume47
Issue number5
DOIs
StatePublished - 1998

Keywords

  • Chemical libraries
  • Polyethylene glycol-polystyrene (PEG- PS)
  • Polymeric supports
  • Solid-phase combinatorial chemistry
  • Solid-phase peptide synthesis

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